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CAS RN: 64-86-8 | 產品號碼: C0380
Colchicine (contains 5% Ethyl Acetate at maximum)
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* TCI會時常優化儲存條件,儲存溫度請以在線目錄為準，敬請留意。
| 產品號碼 | C0380 |
純度/分析方法 
|
>97.0%(HPLC) |
| 分子式 / 分子量 | C__2__2H__2__5NO__6 = 399.44 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Light Sensitive,Hygroscopic |
| 包裝和容器
|
500MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 64-86-8 |
| Reaxys-RN | 2228813 |
| PubChem Substance ID | 87565511 |
| Merck Index(14) | 2471 |
| MDL編號 | MFCD00078484 |
產品規格
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Nonaqueous Titration) | min. 95.0 %(calcd.on dried substance) |
| Specific rotation [a]20/D | -230 to -245 deg(C=1, EtOH) |
| Drying loss | max. 5.0 % |
性質
| 熔點 | 150 °C |
| 比旋光 [α]D | -238° (C=1,EtOH) |
| 水溶性 | Soluble |
| 溶解性（可溶於） | Methanol |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H300 : Fatal if swallowed. H371 : May cause damage to organs. H340 : May cause genetic defects. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相關法規
| RTECS # | GH0700000 |
運輸資料
| UN編號 | UN1544 |
| 類別 | 6.1 |
| 包裝類別 | III |
| HS編碼* | 2939.79-000 |
Application
Colchicine: An Antimitotic Alkaloid
Colchicine is an alkaloid, extracted from plants of the genus Colchicum. Colchicine inhibits β-tubulin polymerization into microtubules by binding to tubulin. Thus, colchicine is an antimitotic agent with a great pharmaceutical potential as an antitumor agent. Colchicine also inhibits neutrophil motility and activity, leading to a net anti-inflammatory effect. (The product is for research purpose only.)
References
- Antitumor Agents. 199.Three-Dimensional Quantitative Structure-Activity Relationship Study of the Colchicine Binding Site Ligands Using Comparative Molecular Field Analysis
- Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain
- Anti-mitotic activity of colchicine and the structural basis for its interaction with tubulin (a review)
- An Overview of Tubulin Inhibitors That Interact with the Colchicine Binding Site (a review)
- Colchicine today (a review)
考研文獻
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