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CAS RN: 50-63-5 | 產品號碼: C2301
Chloroquine Diphosphate
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補充產品訊息:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| 產品號碼 | C2301 |
純度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__1__8H__2__6ClN__3·2H__3PO__4 = 515.86 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 50-63-5 |
| Reaxys-RN | 4223142 |
| PubChem Substance ID | 87560990 |
| SDBS (AIST Spectral DB) | 52374 |
| Merck Index(14) | 2163 |
| MDL編號 | MFCD00069852 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
性質
| 熔點 | 199 °C(dec.) |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H302 : Harmful if swallowed. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相關法規
| RTECS # | VB2450000 |
運輸資料
| HS編碼* | 2933.49-000 |
Application
Exosome research
References
- Interfering with endolysosomal trafficking enhances release of bioactive exosomes
Application
Chloroquine Diphosphate: A Derivative of 4-Aminoquinoline with Autophagy Inhibitory, Antimalarial and Anticancer Activities
Chloroquine diphosphate is a derivative of 4-aminoquinoline, which is an inhibitor of autophagy and has antimalarial and anticancer activities.1-3) In addition, chloroquine has been also reported to exert anti-corona viral activity, including anti-SARS-CoV-2, in vitro.4-6) The mechanism of action of chloroquine is not completely understood. But, some studies have demonstrated that chloroquine is a weak base and may exert its effect by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. In addition, while chloroquine can inhibit certain enzymes, its effect is believed to result, at least in part from its interaction with DNA. (The product is for research purpose only.)
References
- 1) Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion
- 2) Antimalarial Agents: Chloroquine, Hydroxychloroquine, and Quinacrine (a review)
- 3) Chloroquine inhibits cell growth and induces cell death in A549 lung cancer cells
- 4) In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine
- 5) Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro
- 6) Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection
- 7) Chloroquine phosphate (a review on the physical properties, synthesis, metabolites, and methods of analysis)
- 8) Sensitive and rapid liquid chromatography/tandem mass spectrometric assay for the quantification of chloroquine in dog plasma
Application
Reagent for itching model
Reference
- Kappa opioid agonists suppress chloroquine-induced scratching in mice
PubMed Literature
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