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Product Document Searching Made Easy by 2D Code! | TCI Life Science News August 2025 | [Product Highlights] Puberulic Acid: A Compound with... | Various analytical charts can be searched on each product detail page and Product Document Search (The kinds of analytical charts differ by product)
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CAS RN: 59865-13-3 | 產品號碼: C2408
| 產品號碼 | C2408 |
純度/分析方法 
|
>97.0%(HPLC)(N) |
| 分子式 / 分子量 | C__6__2H__1__1__1N__1__1O__1__2 = 1,202.64 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Refrigerated (0-10°C) |
| 應避免的情況 | Heat Sensitive |
| 包裝和容器
|
100MG-Glass Bottle with Plastic Insert （閲覽圖片）, 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 59865-13-3 |
| Reaxys-RN | 3647785 |
| PubChem Substance ID | 125307331 |
| Merck Index(14) | 2752 |
| MDL編號 | MFCD00274558 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(with Total Nitrogen) | min. 97.0 % |
| Melting point | 145.0 to 150.0 °C |
| Specific rotation [a]20/D | -185 to -193 deg(C=0.5, MeOH) |
性質
| 熔點 | 151 °C |
| 比旋光 [α]D | -193° (C=0.5,MeOH) |
| 溶解性（可溶於） | Chloroform |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H302 : Harmful if swallowed. H360 : May damage fertility or the unborn child. H362 : May cause harm to breast-fed children. H350 : May cause cancer. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P263 : Avoid contact during pregnancy/ while nursing. P260 : Do not breathe dusts or mists. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
相關法規
| RTECS # | GZ4120000 |
運輸資料
| HS編碼* | 2941.90-000 |
Application
Paraptosis research / Paraptosis like cell death
Reference
- Endoplasmic reticulum vacuolation and unfolded protein response leading to paraptosis like cell death in cyclosporine A treated cancer cervix cells is mediated by cyclophilin B inhibition
- 1) Assessing the impact of cyclosporin A on lentiviral transduction and preservation of human hematopoietic stem cells in clinically relevant ex vivo gene therapy settings
- Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
- Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation
- The mechanism of action of cyclosporin A and FK506
- Cyclosporin A, FK-506, and rapamycin: Pharmacologic probes of lymphocyte signal transduction
- Mechanisms of action of cyclosporine
- Complex contribution of cyclophilin D to Ca2+-induced permeability transition in brain mitochondria, with relation to the bioenergetic state
- Inhibition of cyclophilin D by cyclosporin A promotes retinal ganglion cell survival by preventing mitochondrial alteration in ischemic injury
Application
Lentivirus vector transduction enhancer
Cyclosporin A improves lentiviral vector transduction efficiency of human hematopoietic stem and progenitor cells.1) Combination of cyclosporine A with prostaglandin E2 further improves the efficiency.
References
Application
Cyclosporin A: A Calcineurin Inhibitor with Immunosuppressive Properties
Cyclosporin A (CsA) is a cyclic polypeptide immunosuppressant, and was initially isolated from the fungus Tolypocladium inflatum Gams in 1970. Cyclosporin A is practically insoluble in water, soluble in diethyl ether, and very soluble in methanol, ethanol and acetonitrile. Cyclosporin A inhibits T-lymphocyte activation, although the exact mechanism of action is not known. Experimental evidence suggests that cyclosporin A is inactive by itself and requires binding to an intracellular protein, cyclophiline D (CypD), for activation in cells. A complex of CsA–CypD, calcium, calmodulin, and calcineurin (a calcium and calmodulin dependent protein phosphatase) is then formed and the phosphatase activity of calcineurin inhibited. This effect may prevent both T-lymphocyte signal transduction and IL-2 transcription. Tacrolimus (FK506) [M2258] is also inhibits calcineurin and is more potent than cyclosporin A. Cyclosporin A is mainly metabolized by cytochrome P 450 IIIA (CYP3A) subfamilies. (The product is for research purpose only.)
References
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