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CAS RN: 244768-32-9 | 產品號碼: C3284
4-[(4-Chloro-2-pyrimidinyl)amino]benzonitrile
![4-[(4-Chloro-2-pyrimidinyl)amino]benzonitrile](/_ui/responsive/theme-tci/images/missing_product_zoom.jpg "4-[(4-Chloro-2-pyrimidinyl)amino]benzonitrile")
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產品規格
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| NMR | confirm to structure |
性質
| 熔點 | 210 °C(dec.) |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. |
相關法規
運輸資料
| HS編碼* | 2933.59-000 |
Application
A synthetic Intermediate of Diarylpyrimidine Antiviral Agents
This product is used for the synthesis of diarylpyrimidine antiviral agents as nonnucleoside reverse transcriptase inhibitors (NNRTIs).
References
- Evolution of anti-HIV drug candidates. Part 3: diarylpyrimidine (DAPY) analogues
- Synthesis of novel diarylpyrimidine analogues and their antiviral activity against human immunodeficiency virus type 1
- Synthesis of novel diarylpyrimidine analogues of TMC278 and their antiviral activity against HIV-1 wild-type and mutant strains
- Discovery of biphenyl-substituted diarylpyrimidines as non-nucleoside reverse transcriptase inhibitors with high potency against wild-type and mutant HIV-1
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