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CAS RN: 113-59-7 | 產品號碼: C3505
Chlorprothixene
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| 產品號碼 | C3505 |
純度/分析方法 
|
>98.0%(T) |
| 分子式 / 分子量 | C__1__8H__1__8ClNS = 315.86 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Refrigerated (0-10°C) |
| 應避免的情況 | Heat Sensitive |
| 包裝和容器
|
1G-Glass Bottle with Plastic Insert （閲覽圖片）, 250MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 113-59-7 |
| Reaxys-RN | 9208755 |
| PubChem Substance ID | 354335789 |
| Merck Index(14) | 2188 |
| MDL編號 | MFCD00869180 |
產品規格
| Appearance | White to Orange to Green powder to crystal |
| Purity(GC) | min. 97.0 % |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 95.0 to 99.0 °C |
| NMR | confirm to structure |
性質
| 熔點 | 97 °C |
| Maximum Wavelength | 324 nm (CH__3CN) |
| 水溶性 | Insoluble |
| 溶解性（可溶於） | Alcohol, Chloroform, Methanol, Ether |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H301 : Toxic if swallowed. H413 : May cause long lasting harmful effects to aquatic life. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相關法規
| RTECS # | XO1050000 |
運輸資料
| UN編號 | UN2811 |
| 類別 | 6.1 |
| 包裝類別 | III |
| HS編碼* | 2934.99-000 |
Application
Chlorprothixene: A Non-Selective Dopamine and 5-Hydroxytryptamine Receptor Antagonist
Chlorprothixene is a thioxanthene neuroleptic used as a typical antipsychotic agent. Reportedly, it works as a non-selective dopamine and 5-hydroxytryptamine (5-HT) receptor antagonist. (The product is for research purpose only.)
References
- Receptor activity and turnover of dopamine and noradrenaline after neuroleptics
- Biologically active conformers of phenothiazines and thioxanthenes. Further evidence for a ligand model of dopamine D2 receptor antagonists
- Effects of chlorprothixene isomers on platelet 5-hydroxytryptamine receptors: evidence for different 5-hydroxytryptamine conformations at uptake and stimulatory sites
- Chlorprothixene [2-chloro-N,N-dimethylthioxanthene-Δ9,γ-propylamine] (a review on the physical properties, synthesis, stability-degradation, drug metabolic products, and methods of analysis.)
- Separation of cis- and trans-isomers of thioxanthene and dibenz[b,e]oxepin derivatives on calixarene- and resorcinarene-bonded high-performance liquid chromatography stationary phases
Application
Chlorprothixene: A Classical Thioxanthene Typical Antipsychotic Agent
Chlorprothixene is a classical thioxanthene typical antipsychotic agent. The mode of action of the thioxanthenes currently not clear, but its dopamine antagonism has been reported. (The product is for research purpose only.)
References
- Pharmacological specificity of conditioned avoidance response inhibition in rats: inhibition by neuroleptics and correlation to dopamine receptor blockade
- Biologically active conformers of phenothiazines and thioxanthenes. Further evidence for a ligand model of dopamine D2 receptor antagonists
- Chlorprothixene (A review on the physical properties, synthesis, stability-degradation, drug metabolic products, and methods of analysis of chlorprothixene)
- Separation of cis- and trans-isomers of thioxanthene and dibenz[b,e]oxepin derivatives on calixarene- and resorcinarene-bonded high-performance liquid chromatography stationary phases
- Detection of antidepressant and antipsychotic drugs in human hair
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