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CAS RN: 188817-13-2 | 產品號碼: C3572
| 產品號碼 | C3572 |
純度/分析方法 
|
>98.0%(HPLC) |
| 分子式 / 分子量 | C__1__7H__1__2ClF__3N__2O = 352.74 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Refrigerated (0-10°C) |
| 應避免的情況 | Heat Sensitive |
| 包裝和容器
|
25MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 188817-13-2 |
| Reaxys-RN | 7719788 |
| PubChem Substance ID | 468591169 |
| MDL編號 | MFCD02179214 |
產品規格
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 7.50 to 8.50 % |
| Melting point | 61.0 to 65.0 °C |
| NMR | confirm to structure |
性質
| 熔點 | 63 °C |
GHS
相關法規
| RTECS # | UQ6457100 |
運輸資料
| HS編碼* | 2933.19-000 |
Application
SC-560: A Selective Cyclooxygenase-1 (COX-1) Inhibitor
SC-560 is a strucutral analog of celecoxib [C2816] and a member of cyclooxygenase (COX) inhibitors which includes selective COX-2 inhibitors such as celecoxib and rofecoxib [R0206]. However, unlike these selective COX-2 inhibitors, SC-560 is a selective COX-1 inhibitor. Reportedly, SC-560 causes intestinal hypermotility, bacterial invasion, inhibition of prostaglandin E2 synthesis, etc. In addition, SC-560 suppresses cell proliferation and induces apoptosis in cancer cells in the blood. (The product is for research purpose only.)
References
- Pharmacological analysis of cyclooxygenase-1 in inflammation
- NSAID-induced gastric damage in rats: requirement for inhibition of both cyclooxygenase 1 and 2
- Inhibition of prostaglandin E2 synthesis by SC-560 is independent of cyclooxygenase 1 inhibition
- Selective COX-1 inhibition: a therapeutic target to be reconsidered (a review)
- The selective cyclooxygenase-1 inhibitor SC-560 suppresses cell proliferation and induces apoptosis in human hepatocellular carcinoma cells
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