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CAS RN: 33564-30-6 | 產品號碼: C3602
Cefoxitin Sodium
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| 產品號碼 | C3602 |
| 純度/分析方法 | >98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__1__6H__1__6N__3NaO__7S__2 = 449.43 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 應避免的情況 | Heat Sensitive |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 33564-30-6 |
| Reaxys-RN | 4104290 |
| PubChem Substance ID | 468591188 |
| Merck Index(14) | 1936 |
| MDL編號 | MFCD00079042 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | +202 to +210 deg(C=1, MeOH) |
| NMR | confirm to structure |
性質
| 熔點 | 204 °C |
| 比旋光 [α]D | 209° (C=1,MeOH) |
| Maximum Wavelength | 260 nm (H__2O) |
| 溶解性（可溶於） | Methanol |
| 溶解性（不溶於） | Aliphatic hydrocarbons |
GHS
相關法規
| RTECS # | XI0330500 |
運輸資料
| HS編碼* | 2941.90-000 |
Application
Cefoxitin Sodium: A Second Generation Cephem Antibiotic against beta-Lactamase
Cefoxitin sodium and its free acid [C3598] are semi-synthetic antibiotic that are derived from cephamycin C which is produced by Streptomyces lactamdurans. Cefoxitins have bactericidal activity against a wide range of Gram-negative and Gram-positive bacteria including aerobes and anaerobes.1,2) Cefoxitins are second generation cephem antibiotics which act by inhibition bacterial cell wall synthesis. Due to the presence of a 7-α methoxy group in the β-lactam ring, cefoxitins exhibit a high degree of stability in the presence of beta-lactamases.1,3)
References
- 1) Cefoxitin: a review of its antibacterial activity, pharmacological properties and therapeutic use
- 2) Bioavailability and pharmacokinetics of cefoxitin sodium (a review)
- 3) AmpC β-Lactamases (a review)
- 4) Cefoxitin, Sodium (A Review on the Properties, Synthesis, Stability, Metabolism, and Methods of Determination of Cefoxitin Sodium)
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