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CAS RN: 149394-66-1 | 產品號碼: C3892
Cidofovir Dihydrate

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產品號碼 | C3892 |
純度/分析方法 | >98.0%(T)(HPLC) |
分子式 / 分子量 | C__8H__1__4N__3O__6P·2H__2O = 315.22 |
外觀與形狀(20°C) | Solid |
儲存條件 | Frozen (-20°C) |
儲存在惰性氣體下 | Store under inert gas |
應避免的情況 | Air Sensitive,Heat Sensitive |
CAS RN | 149394-66-1 |
Reaxys-RN | 25496604 |
MDL編號 | MFCD16556167 |
產品規格
Appearance | White to Light yellow powder to crystal |
Purity(HPLC) | min. 98.0 area% |
Purity(Neutralization titration) | min. 98.0 % |
Water | 11.0 to 12.0 % |
NMR | confirm to structure |
性質
GHS
圖形表示 |
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信號詞 | Warning |
危險性說明 | H315 : Causes skin irritation. H361 : Suspected of damaging fertility or the unborn child. H371 : May cause damage to organs. H341 : Suspected of causing genetic defects. H351 : Suspected of causing cancer. |
防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P405 : Store locked up. |
相關法規
運輸資料
HS編碼* | 2933.59-000 |
Application
Cidofovir: An Acyclic Nucleoside Phosphonate Analog with Activity against a Variety of DNA Viruses.
Cidofovir (HPMPC) is an acyclic nucleoside phosphonate analog with in vitro and in vivo activity against a variety of DNA viruses. There are reports that cidofovir has broad-spectrum antiviral activity against herpesviruses, papillomaviruses, polyomavirus, adenovirus, and poxvirus. Cidofovir undergoes intracellular activation to form its diphosphate, the active metabolite of cidofovir, which are potent inhibitors of viral DNA polymerases. (The product is for research purpose only.)
References
- (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, a potent and selective inhibitor of human cytomegalovirus replication
- HPMPC (cidofovir), PMEA (adefovir) and related acyclic nucleoside phosphonate analogs: a review of their pharmacology and clinical potential in the treatment of viral infections (a review)
- Clinical potential of the acyclic nucleoside phosphonates cidofovir, adefovir, and tenofovir in treatment of DNA virus and retrovirus infections (a review)
- Acyclic nucleoside phosphonates: a key class of antiviral drugs (a review)
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