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CAS RN: 136434-34-9 | 產品號碼: D4223
Duloxetine Hydrochloride
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| 產品號碼 | D4223 |
| 純度/分析方法 | >98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__1__8H__1__9NOS·HCl = 333.87 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 136434-34-9 |
| 相關CAS RN | 116539-59-4 |
| Reaxys-RN | 8168890 |
| PubChem Substance ID | 160871378 |
| Merck Index(14) | 3465 |
| MDL編號 | MFCD06407958 |
產品規格
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 161.0 to 165.0 °C |
| Specific rotation [a]20/D | +120 to +124 deg(C=1, MeOH) |
性質
| 熔點 | 164 °C |
| 比旋光 [α]D | 122° (C=1,MeOH) |
| 溶解性（可溶於） | Methanol |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H361 : Suspected of damaging fertility or the unborn child. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相關法規
| RTECS # | XN0258000 |
運輸資料
| HS編碼* | 2934.99-000 |
Application
Duloxetine Hydrochloride: A Selective Serotonin and Norepinephrine Reuptake Inhibitor (SNRI)
Serotonin (5-hydroxytryptamine [S0370] or 5-HT) and norepinephrine [A0906] are implicated in modulating descending inhibitory pain pathways in the central nervous system. Duloxetine hydrochloride is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) and lacks affinity for monoamine receptors within the central nervous system. Duloxetine hydrochloride is mainly used for the treatment of depression. Although the exact mechanisms of the antidepressant are unknown, these actions are believed to be related to its potentiation of serotonergic and norepinephrinergic activity in the central nervous system.
There are other SNRIs as; (S)-citalopram oxalate [E0958], citalopram hydrobromide [C2370], fluoxetine hydrochloride [F0750], fluvoxamine maleate [F0858], milnacipran hydrochloride [M2133], paroxetine hydrochloride [P1977], sertraline hydrochloride [S0507] and venlafaxine hydrochloride [V0110]. (The product is for research purpose only.)
There are other SNRIs as; (S)-citalopram oxalate [E0958], citalopram hydrobromide [C2370], fluoxetine hydrochloride [F0750], fluvoxamine maleate [F0858], milnacipran hydrochloride [M2133], paroxetine hydrochloride [P1977], sertraline hydrochloride [S0507] and venlafaxine hydrochloride [V0110]. (The product is for research purpose only.)
References
- Effects of duloxetine, a combined serotonin and norepinephrine reuptake inhibitor, on central neural control of lower urinary tract function in the chloralose-anesthetized female cat
- Efficacy of duloxetine, a potent and balanced serotonin-norepinephrine reuptake inhibitor in persistent pain models in rats
- Comparative Affinity of Duloxetine and Venlafaxine for Serotonin and Norepinephrine Transporters in vitro and in vivo, Human Serotonin Receptor Subtypes, and Other Neuronal Receptors
- The dual transporter inhibitor duloxetine: A review of its preclinical pharmacology, pharmacokinetic profile, and clinical results in depression (a review)
- Reliable HPLC method for therapeutic drug monitoring of frequently prescribed tricyclic and nontricyclic antidepressants
- HPLC analysis of the novel antidepressant duloxetine in human plasma after an original solid-phase extraction procedure
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