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CAS RN: 62013-04-1 | 產品號碼: D5495
補充產品訊息:
This product has not been tested for potency and is guaranteed for chemical purity.
| 產品號碼 | D5495 |
純度/分析方法 
|
>98.0%(HPLC)(N) |
| 分子式 / 分子量 | C__4__2H__7__8N__2O__1__4 = 835.09 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Refrigerated (0-10°C) |
| 應避免的情況 | Heat Sensitive |
| 包裝和容器
|
1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 62013-04-1 |
| Reaxys-RN | 6842524 |
| PubChem Substance ID | 468591372 |
| Merck Index(14) | 3354 |
| MDL編號 | MFCD00865041 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC)(CAD) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 186.0 to 190.0 °C |
| Specific rotation [a]20/D | -85.0 to -90.0 deg(C=1, MeOH) |
| NMR | confirm to structure |
性質
| 熔點 | 188 °C |
| 比旋光 [α]D | -88° (C=1,MeOH) |
GHS
相關法規
| RTECS # | JG5806477 |
運輸資料
| HS編碼* | 2941.50-000 |
Application
Dirithromycin: A Macrolide Antibiotic with Outstanding Activity against Campylobacter
Dirithromycin is a macrolide antibiotic derived from erythromycin [E0751]. Dirithromycin is a prodrug, and is hydrolyzed in vivo to its major active metabolite, erythromycilamine.1) Although the antimicrobial spectrum of dirithromycin is similar to that of erythromycin, it reportedly has outstanding activity against Campylobacter.2) In addition, erythromycin inhibits cytochrome P450 isoform 3A4 (CYP3A4), but dirithromycin and azithromycin [A2076] neither inhibit CYP3A4 nor are implicated in clinically significant drug-drug interactions.3) (The product is for research purpose only.)
References
- 1) Synthesis and antimicrobial evaluation of dirithromycin (ASE 136; LY237216), a new macrolide antibiotic derived from erythromycin
- 2) Comparative in vitro activities of new 14-, 15-, and 16-membered macrolides
- 3) Macrolide-induced clinically relevant drug interactions with cytochrome P-450A (CYP) 3A4: an update focused on clarithromycin, azithromycin and dirithromycin (a review)
- 4) Analysis of macrolide antibiotics (a review)
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