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CAS RN: 211915-06-9 | 產品號碼: D5904
Dabigatran Etexilate
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純度/分析方法: >98.0%(T)(HPLC)
别名:
- Ethyl N-[[2-[[4-[N-[(Hexyloxy)carbonyl]carbamimidoyl]anilino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-β-alaninate
- Ethyl 3-[2-[[[4-[N-[(Hexyloxy)carbonyl]carbamimidoyl]phenyl]amino]methyl]-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido]propanoate
文件：
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| 產品號碼 | D5904 |
純度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__3__4H__4__1N__7O__5 = 627.75 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Heat Sensitive |
| 包裝和容器
|
250MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 211915-06-9 |
| Reaxys-RN | 10137269 |
| PubChem Substance ID | 468591633 |
| MDL編號 | MFCD22422841 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Volumetric Analysis) | min. 98.0 % |
| Melting point | 129.0 to 133.0 °C |
| NMR | confirm to structure |
性質
| 熔點 | 131 °C |
GHS
相關法規
運輸資料
| HS編碼* | 2933.39-000 |
Application
Dabigatran Etexilate: An Oral, Reversible Direct Thrombin Inhibitor
Dabigatran etexilate is an oral, reversible direct thrombin inhibitor, and a prodrug of dabigatran [D5902]. Thrombin enables the conversion of fibrinogen into fibrin during the blood coagulation cascade. The inhibition prevents the development of a thrombus. Therefore, thrombin-induced platelet aggregation are inhibited by the active metabolite, dabigatran. In clinical, it is used as an alternative to warfarin [W0005] and does not require monitoring of blood coagulation parameters by blood tests. (The product is for research purpose only.)
References
- Advancement in antithrombotics for stroke prevention in atrial fibrillation (a review)
- Dabigatran etexilate - a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity (a review)
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