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CAS RN: 56390-09-1 | 產品號碼: E0840

Epirubicin Hydrochloride


纯度/分析方法: >95.0%(HPLC)
別名
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10MG
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產品號碼 E0840
純度/分析方法 >95.0%(HPLC)
分子式 / 分子量 C__2__7H__2__9NO__1__1·HCl = 579.98 
外觀與形狀(20°C) Solid
儲存條件 Frozen (<0°C)
應避免的情況 Heat Sensitive
CAS RN 56390-09-1
Reaxys-RN 4229251
PubChem Substance ID 468591676
Merck Index(14) 3623
MDL編號

MFCD00941448

產品規格
Appearance Light yellow to Yellow to Orange powder to crystal
Purity(HPLC) min. 95.0 area%
Specific rotation +310 to +340 deg(C=0.05, methanol)(calcd.on anh.substance)
Water max. 8.0 %
性質
熔點 185 °C
比旋光 [α]D 310° (C=0.05,MeOH)
Maximum Wavelength 497(H2O) nm
水溶性 Slightly soluble
溶解性(微溶於) Methanol
GHS
圖形表示 Pictogram Pictogram
信號詞 Danger
危險性說明 H302 : Harmful if swallowed.
H360 : May damage fertility or the unborn child.
H340 : May cause genetic defects.
H350 : May cause cancer.
防範說明 P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
P405 : Store locked up.
相關法規
RTECS # QI9295750
運輸資料
HS編碼* 2941.90-000
*此H.S.編碼用於日本出口報關, 不適用於您所在國家或地區的進口申報
Application
Epirubicin Hydrochloride: An Anthracycline Antibiotic Cytotoxic Agent with a Better Toxicity Profile

Epirubicin hydrochloride is the 4’-epimer of the anthracycline antibiotic cytotoxic agent, doxorubicin [D4193]. The precise mechanisms of epirubicin’s cytotoxic and/or antiproliferative properties have not been completely elucidated. However, it has been reported that epirubicin forms a complex with DNA by intercalation of its planar rings between nucleotide base pairs, with consequent inhibition of nucleic acid (DNA and RNA) and protein synthesis. After intercalation between DNA base pairs, epirubicin stabilizes the topoisomerase II-DNA complex, resulting in irreversible DNA strand breakage and cytocidal activity.1-3)
Epirubicin has been shown to have a better toxicity profile than doxorubicin. The formation of glucuronide conjugates, not seen with doxorubicin, is observed with epirubicin. The reason for this is thought to be the inversion of the OH group at the 4' position in epirubicin, which facilitates the reaction of glucuronyl transferase. This facilitates excretion and may contribute to the reduced toxicity of epirubicin compared to doxorubicin.4) In clinical, epirubicin hydrochloride has been used alone or in combination with other cytotoxic chemotherapeutic agents in the treatment of a variety of malignancies. (The product is for research purpose only.)

References


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