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CAS RN: 76095-16-4 | 產品號碼: E1010
Enalapril Maleate
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| 產品號碼 | E1010 |
純度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__2__0H__2__8N__2O__5·C__4H__4O__4 = 492.53 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| 包裝和容器
|
1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 76095-16-4 |
| 相關CAS RN
|
75847-73-3 |
| Reaxys-RN | 3645274 |
| PubChem Substance ID | 253661645 |
| Merck Index(14) | 3567 |
| MDL編號 | MFCD00133304 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Specific rotation [a]20/D | -40.0 to -43.0 deg(C=1, MeOH) |
性質
| 熔點 | 144 °C(dec.) |
| 比旋光 [α]D | -41° (C=1,MeOH) |
| Maximum Wavelength | 208 nm (MeOH) |
| 水溶性 | Slightly soluble |
| Degree of solubility in water | 25 g/l 25 °C |
| 溶解性（可溶於） | Ethanol |
| 溶解性（不溶於） | Ether |
GHS
相關法規
| RTECS # | TW3666000 |
運輸資料
| HS編碼* | 2933.99-000 |
Application
Enalapril Maleate: An Angiotensin-Converting Enzyme Inhibitor (ACEI)
Enalapril maleate is an angiotensin-converting enzyme inhibitor (ACEI) without a mercapto group, used in the treatment of hypertension. Enalapril is a prodrug which is hydrolysed by various esterases in the host's liver to form the ACEI, enalaprilat [E1302]. Enalapril increases plasma renin activity (PRA) and decreases plasma concentrations of angiotensin II and aldosterone. (The product is for research purpose only.)
References
- Enalapril maleate (MK-421), a potent, nonsulfhydryl angiotensin-converting enzyme inhibitor: absorption, disposition, and metabolism in man (a review)
- Enalapril. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension and congestive heart failure (a review)
- Enalapril maleate (a review)
- Enalapril: pharmacokinetic/dynamic inferences for comparative developmental toxicity (a review)
考研文獻
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