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CAS RN: 88321-09-9 | 產品號碼: E1337
E-64d [for Biochemical Research]
![Chemical Structure of E-64d [for Biochemical Research]](/medias/E1337.jpg?context=bWFzdGVyfHJvb3R8NDAzNjZ8aW1hZ2UvanBlZ3xhRFUwTDJobFpDODRPVEl4TmpZMk9UUTFNRFUwTDBVeE16TTNMbXB3Wnd8ZmQwZDliNWYyNWRlNjg2MjU5ZjAzZWFiMzdmNTVlMDMyNGZhNzNmMWI3NGJmZDRhZWE1YjQwOGI3N2ZmMmNjNA "E-64d [for Biochemical Research]")
![Thumbnail of E-64d [for Biochemical Research]](/medias/E1337.jpg?context=bWFzdGVyfHJvb3R8MTMwMDB8aW1hZ2UvanBlZ3xhR0ZpTDJnMVl5ODRPVE0xTURnNU9UWXpNRE00TDBVeE16TTNMbXB3Wnd8ZTI0NGQ2OGY2YzI2MzcwYTBiYmY5ZjM1MTI3ODlmYjAxYmY0ZmE0Y2EwMzRiMjE2ZGExNzA0YmViM2UwNjFhNw)
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![E-64d [for Biochemical Research]](/_ui/responsive/theme-tci/images/missing_product_zoom.jpg "E-64d [for Biochemical Research]")
純度/分析方法: >95.0%(HPLC)
别名:
- Loxistatin
- Ethyl (2S,3S)-3-[[(2S)-4-Methyl-1-[(3-methylbutyl)amino]-1-oxo-2-pentanyl]carbamoyl]-2-oxiranecarboxylate
- (2S,3S)-3-[[(2S)-4-Methyl-1-[(3-methylbutyl)amino]-1-oxo-2-pentanyl]carbamoyl]-2-oxiranecarboxylic Acid Ethyl Ester
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產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Specific rotation [a]20/D | +48.0 to +53.0 deg(C=1, EtOH) |
性質
| 熔點 | 126 °C |
| 比旋光 [α]D | 49° (C=1,MeOH) |
GHS
相關法規
| RTECS # | RR0404300 |
運輸資料
| HS編碼* | 2924.29-000 |
Application
E-64d: A Potent and Irreversible Cysteine Protease Inhibitor
Cysteine proteases are enzymes containing nucleophilic cysteine thiol that are important in protein degradation pathway. E-64d (loxistatin) is a cell-permeable ethyl ester of E-64c which is a potent and irreversible cysteine protease inhibitor.
References
- In vitro and in vivo inhibition of cysteine proteinases by EST, a new analog of E-64
- Thiol protease-specific inhibitor E-64 arrests human epidermoid carcinoma A431 cells at mitotic metaphase
- Determination of a cysteine protease inhibitor and its ethyl ester in mouse serum and muscle by liquid chromatography-mass spectrometry
- プロテアーゼインヒビターとプロドラッグデザイン
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