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CAS RN: 66575-29-9 | 產品號碼: F0855
| 產品號碼 | F0855 |
純度/分析方法 
|
>95.0%(HPLC) |
| 分子式 / 分子量 | C__2__2H__3__4O__7 = 410.51 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| 包裝和容器
|
10MG-Glass Bottle with Plastic Insert （閲覽圖片）, 50MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 66575-29-9 |
| Reaxys-RN | 4300863 |
| PubChem Substance ID | 253661985 |
| Merck Index(14) | 2476 |
| MDL編號 | MFCD00082317 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Melting point | 226.0 to 230.0 °C |
性質
| 熔點 | 228 °C |
| 比旋光 [α]D | -17° |
| Maximum Wavelength | 305 nm |
GHS
相關法規
| RTECS # | QL6150000 |
運輸資料
| HS編碼* | 2932.99-000 |
Application
Research on regenerative medicine
Forskolin was utilized for establishing chemically induced pluripotent stem cells (iPSCs) as one of the chemical “substitutes” of Oct4, which is one of four transcription factors (Oct4, Klf4, Sox2, and c-Myc or Oct4, Sox2, Nanog, and Lin28).1) It also induces differentiation of mesenchymal stem cells into neuron-like cells.2)
References
- 1) Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds
- 2) cAMP induces neuronal differentiation of mesenchymal stem cells via activation of extracellular signal-regulated kinase/MAPK
Application
Forskolin: A Diterpene Activator of Cyclic AMP-Generating Systems
Forskolin (also called Coleonol) is a diterpene that is produced by the Indian Coleus plant (Coleus forskohlii). Forskolin directly activates adenylyl cyclase (AC) and raises 3',5'-cyclic AMP (cAMP) levels in a wide variety of cell types. AC catalyzes the conversion of ATP to cAMP and pyrophosphate. cAMP is an important second messenger important in many biological processes.
References
- Forskolin: Unique diterpene activator of adenylate cyclase in membranes and in intact cells
- Forskolin: its biological and chemical properties (a review)
- K. B. Seamon, J. W. Daly, Adv. Cyclic Nucleotide Protein Phosphorylation Res. 1986, 20, 1.
- Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action? (a rview)
- Apoptosis in cerebellar granule cells is blocked by high KCl, forskolin, and IGF-1 through distinct mechanisms of action: the involvement of intracellular calcium and RNA synthesis
- Forskolin as a tool for examining adenylyl cyclase expression, regulation, and G protein signaling (a review)
考研文獻
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