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CAS RN: 26016-99-9 | 產品號碼: F0889
Fosfomycin Disodium Salt
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產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC)(CAD) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | -3.5 to -5.5 deg(C=5, H2O) |
性質
| 比旋光 [α]D | -5° (C=5,H2O) |
| 溶解性（微溶於） | Methanol |
GHS
相關法規
| RTECS # | SZ7902000 |
運輸資料
| HS編碼* | 2941.90-000 |
Application
Fosfomycin: A Broad-Spectrum Antibiotic with Inactivating UDP-N-Acetylglucosamine-3-enolpyruvyl Transferase (MurA)
Fosfomycin (also known as phosphomycin), a broad-spectrum antibiotic, was isolated from Streptomyces fradiase in 1969. It can now be made by chemical synthesis. Fosfomycin has bactericidal activity against a wide range of bacteria, including Gram-negative micro-organisms and some Gram-positive bacteria, such as staphylococci. Fosfomycin interferes with cell wall synthesis in bacteria by inhibiting the initial step by inactivating UDP-N-acetylglucosamine-3-enolpyruvyl transferase, also known as MurA.
References
- Mechanism of action of fosfomycin (phosphonomycin)
- Structure of UDP-N-acetylglucosamine enolpyruvyl transferase, and enzyme essential for the synthesis of bacterial peptidoglycan, complexed with substrate UDP-N-acetylglucosamine and the drug fosfomycin
- Kinetics, Stoichiometry, and Identification of the Reactive Thiolate in the Inactivation of UDP-GlcNAc Enolpyruvoyl Transferase by the Antibiotic Fosfomycin
- Characterization of a Cys115 to Asp substitution in the Escherichia coli cell wall biosynthetic enzyme UDP-GlcNAc Enolpyruvyl Transferase (MurA) that confers resistance to inactivation by the antibiotic fosfomycin
- Fosfomycin for the treatment of multidrug-resistant, including extended-spectrum β-lactamase producing, Enterobacteriaceae infections: a systematic review
- Fosfomycin: evaluation of the published evidence on the emergence of antimicrobial resistance in Gram-negative pathogens (a review)
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