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CAS RN: 33342-05-1 | 產品號碼: G0332
| 產品號碼 | G0332 |
純度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__2__7H__3__3N__3O__6S = 527.64 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| 包裝和容器
|
1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 33342-05-1 |
| Reaxys-RN | 1559726 |
| PubChem Substance ID | 87560715 |
| SDBS (AIST Spectral DB) | 52393 |
| Merck Index(14) | 4443 |
| MDL編號 | MFCD00631870 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 177.0 to 188.3 °C |
性質
| 熔點 | 179 °C |
GHS
相關法規
| RTECS # | DB1584250 |
運輸資料
| HS編碼* | 2935.90-000 |
Application
Gliquidone: A Sulfonylurea ATP-Dependent K+ Channel Antagonist
Gliquidone belongs to sulfonylurea antidiabetics which increase the release of insulin from pancreatic B-cells. Sulfonylurea antidiabetics inhibit ATP-gated K+ channels and thereby cause depolarization of the B-cell membrane. The depolarization leads to activation of voltage-dependent Ca channels and Ca2+ influx into the B-cell, and eventually increases insulin release. (The product is for research purpose only.)
References
- The receptor for antidiabetic sulfonylureas controls the activity of the ATP-modulated K+ channel in insulin-secreting cells
- Glucose, sulfonylureas, and neurotransmitter release: role of ATP-sensitive K+ channels
- Gliquidone, an ATP-dependent K+ channel antagonist, antagonizes morphine-induced hypermotility
- Development of a RP-HPLC method for screening potentially counterfeit anti-diabetic drugs
- Simultaneous determination of gliquidone, pioglitazone hydrochloride, and verapamil in formulation and human serum by RP-HPLC
考研文獻
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