Maintenance Notice (3:00 AM - 8:30 AM November 1, 2025 UTC): This website is scheduled to be unavailable due to maintenance. We appreciate your patience and understanding.
Product Document Searching Made Easy by 2D Code! | TCI Chemistry News October 2025 | [Product Highlights] Tetraphenylethylene Derivatives Used for... | Various analytical charts can be searched on each product detail page and Product Document Search (The kinds of analytical charts differ by product)
Maximum quantity allowed is 999
请选择数量
CAS RN: 383418-30-2 | 產品號碼: H1553
HPA-12
×
![]()
×
| 包裝 | 價格 | 同一天 | 2-3个工作日 | 左側以上貨期 |
貨期資訊
|
|---|---|---|---|---|---|
| 5MG |
NT$13,524
|
10 | 0 | 下單後約2週內可以出貨 |
* 以上價格已含運費關稅等但一些需要海運以及乾冰運輸的產品除外,詳情請與
當地經銷商
洽詢。
* TCI會時常優化儲存條件,儲存溫度請以在線目錄為準，敬請留意。
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 3.60 to 4.10 % |
| NMR | confirm to structure |
性質
| 比旋光 [α]D | -38.9° (C=0.36,CHCl3) |
GHS
相關法規
運輸資料
| HS編碼* | 2924.29-000 |
Application
HPA-12: An Important Ceramide-Trafficking Inhibitor
HPA-12 is a ceramide (Cer) -trafficking inhibitor that was first discovered and synthesized by Hanada and Kobayashi et al.1-3) Ceramide is synthesized in the endoplasmic reticulum (ER) and is transported to the Golgi apparatus, where it is converted to sphingomyelin, by means of the ceramide transport protein (CERT). HPA-12 inhibits the CERT,6) and has been used as a CERT inhibitor in various biological science studies.7-12) For example, HPA-12 possesses antiviral and antibacterial properties against the growth of hepatitis C virus (HCV) and the obligate intracellular bacteria Chlamydiae in cultured human cells.7,10,11) In addition, the CERT inhibition results in resensitization of cancer cells to chemotherapeutic agents such as paclitaxel [ P1632].8) Meanwhile, a point mutation of CERT gene, which dysregulates the function of CERT,14) causes a mental retardation disorder with autosomal dominant inheritance.13) Therefore, inhibition of CERT may represent medical strategies, such as anti-infective and anticancer chemotherapy. (The product is for research purpose only.)
References
- 1)A novel inhibitor of ceramide trafficking from the endoplasmic reticulum to the site of sphingomyelin synthesis
- 2)Revised Stereochemistry of Ceramide-Trafficking Inhibitor HPA-12 by X-ray Crystallography Analysis
- 3)Identification of Novel CERT Ligands as Potential Ceramide Trafficking Inhibitors
- 4)Molecular machinery for non-vesicular trafficking of ceramide
- 5)Co-evolution of sphingomyelin and the ceramide transport protein CERT (a review)
- 6)CERT mediates intermembrane transfer of various molecular species of ceramides
- 7)Host sphingolipid biosynthesis as a target for hepatitis C virus therapy
- 8)Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs
- 9)Decreased ceramide transport protein (CERT) function alters sphingomyelin production following UVB irradiation
- 10)Critical role of virion-associated cholesterol and sphingolipid in hepatitis C virus infection
- 11)Chlamydia trachomatis co-opts GBF1 and CERT to acquire host sphingomyelin for distinct roles during intracellular development
- 12)Trafficking of Acetyl-C16-Ceramide-NBD with Long-Term Stability and No Cytotoxicity into the Golgi Complex
- 13)Large-scale discovery of novel genetic causes of developmental disorders
- 14)Interorganelle trafficking of ceramide is regulated by phosphorylation-dependent cooperativity between the PH and START domains of CERT
PubMed Literature
文檔
產品文件 （部分產品的分析圖譜無法提供，敬請諒解。）
SDS
請選擇語言。
請求的SDS不可用。
如需更多幫助，請聯繫我們 。
產品規格
檢驗報告(CoA)及其他文檔
請輸入批號
輸入的批號不正確
示例 CoA
可下載CoA示例。注：該示例可能非最新批次的CoA。
目前沒有該產品的 CoA 示例。
分析圖譜
請輸入批號
輸入的批號不正確
很抱歉，您搜索的分析圖譜無法提供。