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CAS RN: 3420-72-2 | 產品號碼: H1571
| 產品號碼 | H1571 |
純度/分析方法 
|
>98.0%(GC) |
| 分子式 / 分子量 | C__1__8H__1__8O__5 = 314.34 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| 包裝和容器
|
1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 3420-72-2 |
| 相關CAS RN
|
37951-13-6 |
| Reaxys-RN | 2009865 |
| PubChem Substance ID | 354334221 |
| MDL編號 | MFCD00017174 |
產品規格
| Appearance | Light yellow to Brown powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 112.0 to 116.0 °C |
性質
| 熔點 | 114 °C |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防範說明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相關法規
運輸資料
| HS編碼* | 2914.50-000 |
Application
Flavokawain A: An Apoptosis Inducing Agent
Flavokawain A, a major 2'-hydroxy-chalcone derived from kava plant extract, has recently demonstrated promising anti-cancer and anti-inflammatory activities. Some studies have shown that flavokawain A decreases cyclin-dependent kinase-2 (CDK2) inducing G2/M arrest in vitro, and then it has antiproliferative and apoptotic effects in cancer cells. In addition, it has been reported that flavokawain A suppresses expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). (The product is for research purpose only.)
References
- Flavokawain A, a Novel Chalcone from Kava Extract, Induces Apoptosis in Bladder Cancer Cells by Involvement of Bax Protein-Dependent and Mitochondria-Dependent Apoptotic Pathway and Suppresses Tumor Growth in Mice
- Natural and synthetic 2'-hydroxy-chalcones and aurones: Synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity
- Effects of the Kava chalcone flavokawain A differ in bladder cancer cells with wild-type versus mutant p53
- Suppression of iNOS and COX-2 expression by flavokawain A via blockade of NF-κB and AP-1 activation in RAW 264.7 macrophages
- HPLC analysis of flavokavins and kavapyrones from Piper methysticum Forst.
- Detection of flavokavins (A, B, C) in cultivars of kava (Piper methysticum) using high performance thin layer chromatography (HPTLC)
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