Maximum quantity allowed is 999
请选择数量
CAS RN: 138402-11-6 | 產品號碼: I0859
| 產品號碼 | I0859 |
純度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__2__5H__2__8N__6O = 428.54 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| 包裝和容器
|
1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 138402-11-6 |
| Reaxys-RN | 6620400 |
| PubChem Substance ID | 172088930 |
| Merck Index(14) | 5083 |
| MDL編號 | MFCD00864464 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 184.0 to 188.0 °C |
性質
| 熔點 | 188 °C |
| 水溶性 | Insoluble |
GHS
| 危險性說明 | H413 : May cause long lasting harmful effects to aquatic life. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. |
相關法規
| RTECS # | HM2950270 |
運輸資料
| HS編碼* | 2933.29-000 |
Application
Selective AT1 Subtype Angiotensin II Receptor Antagonists
References
- Angiotensin Type 1 Receptor Blockers Induce Peroxisome Proliferator-Activated Receptor-gamma Activity
- Selective angiotensin II receptor antagonism reduces insulin resistance in obese Zucker rats
- Pharmacological characterization of SR 47436, a new nonpeptide AT1 subtype angiotensin II receptor antagonist
- C. Cazaubon, J. Gougat, F. Bousquet, P. Guiraudou, R. Gayraud, C. Lacour, A. Roccon, G. Galindo, G. Barthelemy, B. Gautret, J. Pharmacol. Exp. Ther. 1993, 265, 826.
- Role of cytochrome P-4502C9 in irbesartan oxidation by human liver microsomes
- M. Bourrié, V. Meunier, Y. Berger, G. Fabre, Drug Metab. Dispos. 1999, 27, 288.
Application
Irbesartan: A Long-Active Specific Competitive Angiotensin II Type 1 (AT1) Receptor Antagonist
Angiotensin II, a peptide hormone, is a potent vasoconstrictor formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE). Angiotensin II can activate two different receptors, AT1 and AT2, both of which are coupled to G-protein. The most important vasoconstrictor actions of angiotensin II are mediated through AT1 receptors. Irbesartan is a long-active specific competitive antagonist of AT1 receptors with a much greater affinity for the AT1 receptor than for the AT2 receptor, and no agonist activity. Irbesartan selectively binds to the AT1 receptor and competitively binds the endogenous hypertensive (vasoconstrictor) substance angiotensin II, and has an antihypertensive effect. For your reference, [B4143] is a key synthetic intermediate of irbesartan. (The product is for research purpose only.)
References
- Irbesartan: a review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in the management of hypertension
- The new angiotensin II receptor antagonist, irbesartan: pharmacokinetic and pharmacodynamics considerations (a review)
考研文獻
產品介紹報導
產品文件 （部分產品的分析圖譜無法提供，敬請諒解。）
SDS
請選擇語言。
請求的SDS不可用。
如需更多幫助，請聯繫我們 。
產品規格
檢驗報告(CoA)及其他文檔
請輸入批號
輸入的批號不正確
示例 CoA
可下載CoA示例。注：該示例可能非最新批次的CoA。
目前沒有該產品的 CoA 示例。
分析圖譜
請輸入批號
輸入的批號不正確
很抱歉，您搜索的分析圖譜無法提供。