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CAS RN: 74103-07-4 | 產品號碼: K0053
Ketorolac Tromethamine
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| 產品號碼 | K0053 |
純度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__1__5H__1__3NO__3·C__4H__1__1NO__3 = 376.41 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| 包裝和容器
|
1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 74103-07-4 |
| 相關CAS RN
|
74103-06-3 |
| Reaxys-RN | 6463165 |
| PubChem Substance ID | 253661330 |
| Merck Index(14) | 5306 |
| MDL編號 | MFCD00887595 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
性質
| 熔點 | 167 °C |
| Maximum Wavelength | 322 nm (MeOH) |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H301 : Toxic if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相關法規
| RTECS # | UY7759900 |
運輸資料
| UN編號 | UN2811 |
| 類別 | 6.1 |
| 包裝類別 | III |
| HS編碼* | 2933.99-000 |
Application
Ketorolac Tromethamine: A Non-Selective Cyclooxygenase (COX) Inhibitor with Strong Analgesic Activity
Ketorolac tromethamine is a non-steroidal anti-inflammatory drug (NSAID) with strong analgesic activity. Ketorolac is a non-selective cyclooxygenase (COX) inhibitor. Thus, it reduces prostaglandin synthesis. Ketorolac is the racemic mixture of (-)-S and (+)-R enantiomers. Most of its analgesic and COX inhibitory activity is retained in the S-isomer. Besides, some formulations for controlled release of ketorolac tromethamine have been reported. Ketorolac and its metabolites are excreted primarily by the kidneys. For your reference, [B4934] is used as a synthetic intermediate of ketorolac. (The product is for research purpose only.)
References
- The analgesic and anti-inflammatory profile of ketorolac and its tromethamine salt
- Ketorolac tromethamine absorption, distribution, metabolism, excretion, and pharmacokinetics in animals and humans
- Ketorolac. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential
- Semiinterpenetrating polymer network microspheres of gelatin and sodium carboxymethyl cellulose for controlled release of ketorolac tromethamine
- Ketorolac tromethamine formulations: an overview
- HPTLC determination of ketorolac tromethamine
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