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Published TCIMAIL newest issue No.200 | Product Document Searching Made Easy by 2D Code! | TCI Life Science News December 2025 | [Product Highlights] Catechol-containing Methacrylate Monomer for... | Various analytical charts can be searched on each product detail page and Product Document Search (The kinds of analytical charts differ by product)
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CAS RN: 921902-48-9 | 產品號碼: K0077
KN3014
×
純度/分析方法: >98.0%(T)(HPLC)
别名:
- N-[2-(1-Methyl-1,2,3,4-tetrahydroquinolin-6-yl)-2-(piperidin-1-yl)ethyl]-2-(o-tolyloxy)acetamide
- 2-(2-Methylphenoxy)-N-[2-(1-methyl-1,2,3,4-tetrahydro-6-quinolinyl)-2-(1-piperidinyl)ethyl]acetamide
文件：
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| 產品號碼 | K0077 |
純度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__2__6H__3__5N__3O__2 = 421.59 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Heat Sensitive |
| CAS RN | 921902-48-9 |
| Reaxys-RN | 38211687 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 136.0 to 140.0 °C |
| NMR | confirm to structure |
性質
| 熔點 | 138 °C |
GHS
相關法規
運輸資料
| HS編碼* | 2933.49-000 |
Application
KN3014: A Small Compound Targeting the Interaction between NLRP3-PYD and ASC-PYD of the NLRP3 Inflammasome
KN3014, developed by Masumoto et al, is a small compound containing a piperidine ring that directly inhibits the interaction between the PYDs (pyrin domains) of NLRP3 and ASC (apoptosis associated speck-like protein containing a caspase recruitment domain) by protein-protein interaction inhibition screening of wheat germ cell-free synthesized proteins.
References
- KN3014, a piperidine-containing small compound, inhibits auto-secretion of IL-1β from PBMCs in a patient with Muckle–Wells syndrome
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