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CAS RN: 64808-48-6 | 產品號碼: L0278
Lobenzarit Disodium Salt
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產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| NMR | confirm to structure |
性質
| 熔點 | 388 °C(dec.) |
| 水溶性 | Soluble |
| 溶解性（不溶於） | Ether, Acetone, Tetrahydrofuran |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H302 : Harmful if swallowed. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相關法規
| RTECS # | DG4975520 |
運輸資料
| HS編碼* | 2922.49-000 |
Application
Lobenzarit Disodium: An Immunomodulator
Lobenzarit disodium is an immunomodulator and antioxidative agent. Its principle mechanism action seems to be through the subset of T cells. On the other hand, it does not inhibit the biosynthesis of prostaglandins and leukotrienes and is ineffective on acute inflammatory reactions induced in animals. Its hepatoprotective properties are also reported. In addition, the sustained-release tablets of it have been studied. It is used for the treatment of rheumatoid arthritis (RA). (The product is for research purpose only.)
References
- An immunomodulating antirheumatic drug, lobenzarit disodium (CCA): inhibition of polyclonal B-cell activation and prevention of autoimmune disease in MRL/Mp-lpr/lpr mice
- Effects of lobenzarit disodium on human endothelial cells. Lobenzarit disodium inhibits proliferative response, HLA-DR antigen expression, and T cell adherence toward endothelial cells
- Current views on the pharmacological properties of the immunomodulator lobenzarit disodium
- R. Gonzalez, D. Remirez, J. Investig. Allergol. Clin. Immunol. 1997, 7, 77.
- Statistical optimization of a sustained-release matrix tablet of lobenzarit disodium
- Solubility of Lobenzarit Disodium Salt in Ethanol-Water Mixtures
- Potentiometric determination of lobenzarit in bulk drugs
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