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CAS RN: 118288-08-7 | 產品號碼: L0341
| 產品號碼 | L0341 |
| 純度/分析方法 | >98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__2__2H__2__9N__3O__4S = 431.55 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片）, 250MG-Glass Bottle with Plastic Insert （閲覽圖片）, 25MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 118288-08-7 |
| Reaxys-RN | 8045494 |
| PubChem Substance ID | 468592156 |
| Merck Index(14) | 5347 |
| MDL編號 | MFCD00867520 |
產品規格
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 97.0 to 101.0 °C |
性質
| 熔點 | 99 °C |
| 水溶性 | Insoluble |
| 溶解性（可溶於） | Methanol |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H302 : Harmful if swallowed. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相關法規
| RTECS # | AC2957000 |
運輸資料
| HS編碼* | 2934.99-000 |
Application
Lafutidine: A Histamine H2 Receptor Antagonist with Gastric Antisecretory and Gastroprotective Activities
Lafutidine (FRG-8813) is a histamine H2 receptor antagonist with gastric antisecretory and gastroprotective activities. It exhibits potent and long-lasting H2 antagonism and prolonged antisecretion. In addition, it shows gastroprotective effects (increased gastric mucosal blood flow and gastric mucus secretion) against gastric mucosal damage through capsaicin-sensitive afferent nerves.
References
- Gastroprotective activity of FRG-8813, a novel histamine H2-receptor antagonist, in rats
- Unique profile of lafutidine, a novel histamine H2-receptor antagonist-mucosal protection throughout gastrointestinal tract mediated by capsaicin-sensitive afferent neurons (a review)
- Determination of lafutidine in human plasma by high-performance liquid chromatography-electrospray ionization mass spectrometry: Application to a bioequivalence study
- Analytical method development and validation of lafutidine in tablet dosage form by RP-HPLC
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