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CAS RN: 156897-06-2 | 產品號碼: L0348
Licofelone
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| 包裝 | 價格 | 同一天 | 2-3个工作日 | 左側以上貨期 |
貨期資訊
|
|---|---|---|---|---|---|
| 10MG |
NT$6,762
|
10 | 30 | 下單後約2週內可以出貨 |
* 以上價格已含運費關稅等但一些需要海運以及乾冰運輸的產品除外,詳情請與
當地經銷商
洽詢。
* TCI會時常優化儲存條件,儲存溫度請以在線目錄為準，敬請留意。
| 產品號碼 | L0348 |
純度/分析方法 
|
>95.0%(HPLC) |
| 分子式 / 分子量 | C__2__3H__2__2ClNO__2 = 379.88 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Frozen (-20°C) |
| 應避免的情況 | Light Sensitive,Heat Sensitive |
| CAS RN | 156897-06-2 |
| Reaxys-RN | 6823674 |
| MDL編號 | MFCD00929900 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| NMR | confirm to structure |
性質
| 熔點 | 157 °C |
GHS
相關法規
| RTECS # | UY7759650 |
運輸資料
| HS編碼* | 2933.99-000 |
Application
Licofelone: A Dual Inhibitor of Cyclooxygenase (COX) and 5-Lipoxygenase (5-LOX)
Licofelone (ML-3000) is a dual inhibitor of cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) metabolic pathways of arachidonic acid [A0781], and decreases the production of pro-inflammatory leukotrienes and prostaglandins.1-3) There are reports that licofelone is expected to possess clinical advantages over the selective inhibitors of COX enzyme. Licofelone is considered as a treatment for osteoarthritis. In addition, licofelone induces apoptosis in cancer cells.4,5) (The product is for research purpose only.)
References
- 1) Discovery and development of ML3000 (a review)
- 2) The pharmacological profile of ML3000: a new pyrrolizine derivative inhibiting the enzymes cyclo-oxygenase and 5-lipoxygenase (a review)
- 3) Licofelone -A novel analgesic and anti-inflammatory agent (a review)
- 4) Licofelone, a dual COX/5-LOX inhibitor, induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade
- 5) Modulation of smoke-induced DNA and microRNA alterations in mouse lung by licofelone, a triple COX-1, COX-2 and 5-LOX inhibitor
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