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CAS RN: 165800-03-3 | 產品號碼: L0362
| 產品號碼 | L0362 |
純度/分析方法 
|
>98.0%(HPLC) |
| 分子式 / 分子量 | C__1__6H__2__0FN__3O__4 = 337.35 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive |
| 包裝和容器
|
1G-Glass Bottle with Plastic Insert （閲覽圖片）, 250MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 165800-03-3 |
| Reaxys-RN | 7496939 |
| PubChem Substance ID | 468592166 |
| MDL編號 | MFCD00937825 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 177.0 to 181.0 °C |
| Specific rotation | -7.0 to -9.0 deg(C=1, CHCl3) |
性質
| 熔點 | 179 °C |
| Maximum Wavelength | 252 nm (H__2O) |
| 水溶性 | Insoluble |
| Degree of solubility in water | 610 mg/l 25 °C |
| 溶解性（微溶於） | dichloromethane |
| 溶解性（不溶於） | Ethanol |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H372 : Causes damage to organs through prolonged or repeated exposure. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P314 : Get medical advice/ attention if you feel unwell. |
相關法規
| RTECS # | AC2720000 |
運輸資料
| HS編碼* | 2934.99-000 |
Application
Linezolid: A Synthetic Oxazolidinone Antibacterial with Excellent Activity against Gram-Positive Pathogens including Antibiotic-Resistant Bacteria
Linezolid (U-100766) is a synthetic oxazolidinone antibacterial which has excellent activity against virtually all important Gram-positive pathogens, including methicillin-resistant staphylococci (e.g. MRSA), penicillin-resistant pneumococci, macrolide-resistant streptococci, and vancomycin-resistant enterococci (VRE). In addition, the in vitro spectrum of activity of linezolid also includes certain Gram-negative bacteria and anaerobic bacteria. It has been reported that linezolid binds to a site on the bacterial 23S ribosomal RNA of the 50S subunit and prevents the formation of a functional 70S initiation complex, which is an essential component of the bacterial translation process. In recent years, the emergence of bacteria resistant to linezolid has become a problem. (The product is for research purpose only.)
References
- In vitro activities of U-100592 and U-100766, novel oxazolidinone antibacterial agents
- The oxazolidinone linezolid inhibits initiation of protein synthesis in bacteria
- Oxazolidinone structure-activity relationships leading to linezolid (a review)
- Linezolid: the first oxazolidinone antimicrobial (a review)
- The emerging problem of linezolid-resistant Staphylococcus (a review)
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