Maximum quantity allowed is 999
请选择数量
CAS RN: 192725-17-0 | 產品號碼: L0377
| 產品號碼 | L0377 |
| 純度/分析方法 | >98.0%(HPLC) |
| 分子式 / 分子量 | C__3__7H__4__8N__4O__5 = 628.81 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Frozen (-20°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Heat Sensitive |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片）, 250MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 192725-17-0 |
| Reaxys-RN | 9309881 |
| PubChem Substance ID | 468592179 |
| MDL編號 | MFCD22628840 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 103.0 to 107.0 °C |
| Specific rotation | -22.0.0 to -26.0.0 deg(C=0.4, mathanol |
| NMR | confirm to structure |
性質
| 熔點 | 105 °C |
| 水溶性 | Insoluble |
| 溶解性（可溶於） | Ethanol, Methanol |
GHS
相關法規
| RTECS # | UV6264135 |
運輸資料
| HS編碼* | 2933.59-000 |
Application
Lopinavir: A HIV-1 Protease Inhibitor
Lopinavir (ABT-378), a HIV-1 protease inhibitor, prevents cleavage of the Gag-Pol polyprotein, resulting in the production of immature, non-infectious viral particles.1,2) In clinical, lopinavir is co-formulated with ritonavir [R0116] to enhance the bioavailability and pharmacokinetics of lopinavir.3) Ritonavir inhibits the CYP3A-mediated metabolism of lopinavir, thereby providing increased plasma levels of lopinavir. In the 2020s, it has been reported that lopinavir is an effective agent that inhibits the protease activity of corona viruses, such as SARS-CoV2 and MERS.4,5) (The product is for research purpose only.)
References
- 1) ABT-378, a Highly Potent Inhibitor of the Human Immunodeficiency Virus Protease
- 2) Human Serum Attenuates the Activity of Protease Inhibitors toward Wild-Type and Mutant Human Immunodeficiency Virus
- 3) Lopinavir-ritonavir: A new protease inhibitor (a review)
- 4) Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro
- 5) A systematic review of lopinavir therapy for SARS coronavirus and MERS coronavirus-A possible reference for coronavirus disease-19 treatment option
產品文件 （部分產品的分析圖譜無法提供，敬請諒解。）
SDS
請選擇語言。
請求的SDS不可用。
如需更多幫助，請聯繫我們 。
產品規格
檢驗報告(CoA)及其他文檔
請輸入批號
輸入的批號不正確
示例 CoA
可下載CoA示例。注：該示例可能非最新批次的CoA。
目前沒有該產品的 CoA 示例。
分析圖譜
請輸入批號
輸入的批號不正確
很抱歉，您搜索的分析圖譜無法提供。