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CAS RN: 15297-92-4 | 產品號碼: L0422
LDN-22684
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| 包裝 | 價格 | 同一天 | 2-3个工作日 | 左側以上貨期 |
貨期資訊
|
|---|---|---|---|---|---|
| 100MG |
NT$5,838
|
11 | 30 | 下單後約3-4週內可以出貨 |
* 以上價格已含運費關稅等但一些需要海運以及乾冰運輸的產品除外,詳情請與
當地經銷商
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| 產品號碼 | L0422 |
純度/分析方法 
|
>98.0%(HPLC) |
| 分子式 / 分子量 | C__1__5H__1__2O__3 = 240.26 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| 包裝和容器
|
100MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 15297-92-4 |
| Reaxys-RN | 181737 |
| MDL編號 | MFCD00022286 |
產品規格
| Appearance | White to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 142.0 to 146.0 °C |
| NMR | confirm to structure |
性質
| 熔點 | 145 °C |
GHS
相關法規
運輸資料
| HS編碼* | 2932.99-000 |
Application
LDN-22684: A LRRK2 Inhibitor as a Useful Tool for the Study of Parkinson's disease
The leucine-rich repeat kinase 2 (LRRK2) is a large protein (2527 amino acids) with serine-threonine (Ser/Thr) protein kinase activity and autophosphorylation activity. It is highly expressed in many mammal tissues. Genetic mutations in the G2019S encoding portion of LRRK2 (LRRK2-G2019S) have been detected frequently in Parkinson's (PD) patients.1-3) As a result, LRRK2-G2019S is a promising therapeutic target for the treatment of PD. There are reports, that LDN-22684 inhibited LRRK2-G2019S and wild-type LRRK2 in the low micromole range.1,3) Therefore it is a useful tool for the study of PD. (The product is for research purpose only.)
References
- 1) Small Molecule Kinase Inhibitors for LRRK2 and Their Application to Parkinson's Disease Models (a review)
- 2) Chemical Biology of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors (a review)
- 3) Development of a mechanism-based high-throughput screen assay for leucine-rich repeat kinase 2-Discovery of LRRK2 inhibitors
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