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CAS RN: 133073-73-1 | 產品號碼: M1664
Methotrexate Hydrate
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| 產品號碼 | M1664 |
純度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__2__0H__2__2N__8O__5·xH__2O = 454.45 (as Anhydrous) |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Light Sensitive,Hygroscopic |
| 包裝和容器
|
1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 133073-73-1 |
| 相關CAS RN
|
59-05-2 |
| Reaxys-RN | 70669 |
| PubChem Substance ID | 87558856 |
| Merck Index(14) | 5985 |
| MDL編號 | MFCD00150847 |
產品規格
| Appearance | Light yellow to Brown powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 %(calcd.on anh.substance) |
| Specific rotation [a]20/D | +18.0 to +23.0 deg(C=0.1, 1mol/L NaOH sol.)(calcd.on anh.substance) |
| Water | max. 10.0 % |
性質
| 熔點 | 205 °C(dec.) |
| 比旋光 [α]D | 21° (C=0.1,1mol/L NaOH sol.) |
| 水溶性 | Insoluble |
| 溶解性（不溶於） | Alcohol, Chloroform, Ether |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H301 : Toxic if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H360 : May damage fertility or the unborn child. H372 : Causes damage to organs through prolonged or repeated exposure. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相關法規
| RTECS # | MA1225000 |
運輸資料
| UN編號 | UN2811 |
| 類別 | 6.1 |
| 包裝類別 | III |
| HS編碼* | 2933.99-000 |
Application
Quorum sensing inhibitor
Reference
- The Role of Drug Repurposing in the Development of Novel Antimicrobial Drugs: Non-Antibiotic Pharmacological Agents as Quorum Sensing-Inhibitors
Application
Methotrexate: An Inhibitor of Dihydrofolate Reductase (DHFR)
Methotrexate (MTX), analog of folic acid, is an inhibitor of the enzyme dihydrofolate reductase (DHFR) which catalyzes the conversion of dihydrofolate to the active tetrahydrofolate, leading to interfere with folic acid metabolism. Result is inhibition of DNA synthesis and cell proliferation in S phases (the phase of DNA synthesis). Also, MTX has immunosuppressive and anti-inflammatory activity. Although no single mechanism is sufficient to account for all the anti-inflammatory activities of methotrexate, the release of adenosine from cells has been demonstrated. MTX is commonly used for the treatment of certain cancers including leukemia, rheumatoid arthritis, Crohn’s disease and psoriasis. (The product is for research purpose only.)
References
- Mechanisms of action of methotrexate
- Anti-inflammatory mechanisms of methotrexate in rheumatoid arthritis
- Molecular therapeutics: Methotrexate and its mechanism of action
- Intrinsic and acquired resistance to methotrexate in acute leukemia
- Recent insights in the pharmacological actions of methotrexate in the treatment of rheumatoid arthritis
- Methotrexate-how does it really work? (a review)
- Determination of methotrexate in human serum by high-performance liquid chromatography combined with pseudo template molecularly imprinted polymer
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