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CAS RN: 85650-52-8 | 產品號碼: M2151
| 產品號碼 | M2151 |
純度/分析方法 
|
>98.0%(HPLC) |
| 分子式 / 分子量 | C__1__7H__1__9N__3 = 265.36 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| 包裝和容器
|
100MG-Glass Bottle with Plastic Insert （閲覽圖片）, 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 85650-52-8 |
| Reaxys-RN | 549345 |
| PubChem Substance ID | 125307817 |
| SDBS (AIST Spectral DB) | 52906 |
| MDL編號 | MFCD00865427 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 95.0 % |
| Melting point | 119.0 to 123.0 °C |
性質
| 熔點 | 121 °C |
GHS
相關法規
| RTECS # | UQ4410250 |
運輸資料
| HS編碼* | 2933.99-000 |
Application
Mirtazapine: A Noradrenergic and Specific Serotonergic Antidepressant (NaSSA)
Mirtazapine (Org 3770) is the first noradrenergic and specific serotonergic antidepressant (NaSSA). Studies have suggested that mirtazapine acts as an antagonist at central presynaptic α2 adrenergic inhibitory autoreceptors and heteroreceptors, as well as by blocking 5-HT2 and 5-HT3 receptors. Therefore, these antagonisms enhance the release of noradrenaline and 5-HT1A-mediated serotonergic transmission in brain. Mirtazapine is mainly metabolized by CYP1A2, CYP2D6, and CYP3A4. (The product is for research purpose only.)
References
- Neurochemical and autonomic pharmacological profiles of the 6-aza-analog of mianserin, Org 3770 and its enantiomers
- Effect of the alpha-2 adrenoceptor antagonist mirtazapine on the 5-hydroxytryptamine system in the rat brain.
- A review of the pharmacological and clinical profile of mirtazapine
- High-Performance Liquid Chromatographic Method with Diode Array Detection for Identification and Quantification of the Eight New Antidepressants and Five of Their Active Metabolites in Plasma after Overdose
- Chirality in the New Generation of Antidepressants: Stereoselective Analysis of the Enantiomers of Mirtazapine, N-Demethylmirtazapine, and 8-Hydroxymirtazapine by LC-MS
考研文獻
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