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CAS RN: 256373-96-3 | 產品號碼: M3396
MCC950 Sodium Salt
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產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(qNMR) | min. 95.0 % |
| NMR | confirm to structure |
性質
| 熔點 | 239 °C |
GHS
相關法規
運輸資料
| HS編碼* | 2935.90-000 |
Application
MCC 950 Sodium Salt: A Potent and Selective Small-Molecule Inhibitor of the NLRP3 Inflammasome
It has recently been reported that NLR family pyrin domain-containing protein 3 (NLRP3), a pattern recognition receptor, forms a complex called NLRP3 inflammasome in response to irritating metabolites and pathogens, and induces the production of pro-inflammatory cytokines, Interleukin (IL)-1β and IL-18. MCC950 sodium has attracted attention as a potent and selective NLRP3 inflammasome inhibitor which shows anti-inflammatory activity. (The product is for research purpose only.)
References
- A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
- The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction
- MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition
- Target of MCC950 in Inhibition of NLRP3 Inflammasome Activation: a Literature Review
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