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CAS RN: 98-92-0 | 產品號碼: N0078
| 產品號碼 | N0078 |
純度/分析方法 
|
>99.0%(T)(HPLC) |
| 分子式 / 分子量 | C__6H__6N__2O = 122.13 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| 應避免的情況 | Light Sensitive |
| CAS RN | 98-92-0 |
| Reaxys-RN | 383619 |
| PubChem Substance ID | 87573471 |
| SDBS (AIST Spectral DB) | 553 |
| Merck Index(14) | 6523 |
| MDL編號 | MFCD00006395 |
產品規格
| Appearance | White powder to crystal |
| Purity(HPLC) | min. 99.0 area% |
| Purity(Nonaqueous Titration) | min. 99.0 % |
| Melting point | 129.0 to 132.0 °C |
| Solubility in Water | almost transparency |
性質
| 熔點 | 129 °C |
| 沸點 | 336 °C |
| Degree of solubility in water | 1,200 g/l 20 °C |
| 溶解性（微溶於） | Ether |
GHS
| 信號詞 | Warning |
| 危險性說明 | H320 : Causes eye irritation. |
| 防範說明 | P264 : Wash skin thoroughly after handling. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
相關法規
| RTECS # | QS3675000 |
運輸資料
| HS編碼* | 2936.29-000 |
Application
Bacterial spore germinant research
Bacterial spores are more resistant to antibiotics and nutritional deficiencies than their vegetative cells and sometimes cause serious problems from the viewpoint of hygiene in clinical treatment and food processing.1) Spore persistence also plays a major role in the recurrence of infections after antibiotic treatment. Molecules that stimulate germination are termed “germinants”1) and the efficacy of germinant administration combined with antibiotics have been evaluated (for example, reports by N. Budi et al.2,3)). Cogerminants are compounds that do not have germination-stimulating activity in themselves but stimulate germination when combined with other compounds. Nicotinamide has been reported to act as a cogerminant for Clostridium tetani spores when used with L-lactate (L0165), L-methionine (M0099), and Na+.4)
(The product is for research purpose only.)
(The product is for research purpose only.)
References
- 1) Germinants and Their Receptors in Clostridia
- 2) Omadacycline compared to vancomycin when combined with germinants to disrupt the life cycle of Clostridioides difficile.
- 3) Efficacy of Omadacycline or Vancomycin Combined With Germinants for Preventing Clostridioides difficile Relapse in a Murine Model
- 4) The Germination of Spores of Clostuidium tetani
- Hypoglycaemic effects of antidiabetic drugs in streptozotocin-nicotinamide-induced mildly diabetic and streptozotocin-induced severely diabetic rats
Application
Reagent for diabetes mellitus model
References
PubMed Literature
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