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CAS RN: 54-11-5 | 產品號碼: N0079
| 產品號碼 | N0079 |
純度/分析方法 
|
>95.0%(GC)(T) |
| 分子式 / 分子量 | C__1__0H__1__4N__2 = 162.24 |
| 外觀與形狀（20°C） | Liquid |
| 儲存條件
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Hygroscopic |
| CAS RN | 54-11-5 |
| Reaxys-RN | 82109 |
| PubChem Substance ID | 87573472 |
| SDBS (AIST Spectral DB) | 6729 |
| Merck Index(14) | 6524 |
| MDL編號 | MFCD00006369 |
產品規格
| Appearance | Colorless to Red to Green clear liquid |
| Purity(GC) | min. 95.0 % |
| Purity(Nonaqueous Titration) | min. 95.0 % |
| Specific rotation [a]20/D | -160 to -173 deg(C=10, Acetone) |
性質
| 熔點 | -80 °C |
| 沸點 | 91 °C/3 mmHg |
| flp | 95 °C |
| 比重 | 1.02 |
| 比旋光 [α]D | -167° (C=10,Acetone) |
| 折射率 | 1.53 |
| 水溶性 | Completely miscible |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H300 + H310 + H330 : Fatal if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H361 : Suspected of damaging fertility or the unborn child. H370 : Causes damage to organs. H410 : Very toxic to aquatic life with long lasting effects. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P262 : Do not get in eyes, on skin, or on clothing. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P284 : Wear respiratory protection. P391 : Collect spillage. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P361 + P364 : Take off immediately all contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P302 + P352 + P310 : IF ON SKIN: Wash with plenty of water. Immediately call a POISON CENTER/doctor. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P405 : Store locked up. |
相關法規
| RTECS # | QS5250000 |
運輸資料
| UN編號 | UN1654 |
| 類別 | 6.1 |
| 包裝類別 | II |
| HS編碼* | 2939.79-000 |
Application
Nicotine: A Nicotinic Acetylcholine Receptors (nAChRs) Agonist
Nicotine (or (-)-(S)-nicotine) is an alkaloid and natural insecticide that acts as an anti-herbivore chemical in tobacco plants. Nicotine acts as a nicotinic acetylcholine receptors (nAChRs) agonist. nAChRs are a family of ligand-gated ion channels. Recent studies have shown that nicotine activates neuronal nAChRs in peripheral and central nervous systems leading to depolarization of cell membranes and elevation of intracellular calcium levels, which are considered to cause stimulation of neurotransmitter release, synaptic transmission, intracellular signal transduction and gene expression.1) Nicotine is also used as a probe agent for phenotyping cytochrome P450 2A6 (CYP2A6) which is involved in the metabolism of nicotine.2) (The product is for research purpose only.)
References
- 1) Mammalian nicotinic acetylcholine receptors: from structure to function (a review)
- 2) Metabolism and disposition kinetics of nicotine (a review)
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