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CAS RN: 105816-04-4 | 產品號碼: N0912
| 產品號碼 | N0912 |
純度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__1__9H__2__7NO__3 = 317.43 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| 包裝和容器
|
500MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 105816-04-4 |
| Reaxys-RN | 6486870 |
| PubChem Substance ID | 160871031 |
| Merck Index(14) | 6428 |
| MDL編號 | MFCD00875706 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Specific rotation [a]20/D | -36.5 to -40.0 deg(C=1, 0.1mol/L NaOH) |
性質
| 比旋光 [α]D | -38° (C=1,0.1mol/L NaHO sol.) |
| 水溶性 | Insoluble |
| Degree of solubility in water | 0.0066 g/l |
GHS
相關法規
| RTECS # | SQ7318950 |
運輸資料
| HS編碼* | 2924.29-000 |
Application
速効性のATP感受性K+チャンネルアンタゴニスト，ナテグリニド
Nateglinide is a D-phenylalanine derivative which rapidly increases the release of insulin from pancreatic B-cells. More rapidly than that of sulfonylurea antidiabetics, nateglinide inhibits ATP-gated K+ channels and thereby causes depolarization of the B-cell membrane. The depolarization leads to activation of voltage-dependent Ca channels and Ca2+ influx into the B-cell, and eventually increases insulin release. (The product is for research purpose only.)
References
- Hypoglycaemic and insulinotropic effects of a novel oral antidiabetic agent, (－)-N-(trans-4-isopropylcyclohexane-carbonyl)-D-phenylalanine (A-4166)
- The effect of food on the oral bioavailability and the pharmacodynamic actions of the insulinotropic agent nateglinide in healthy subjects
- Pancreatic β-cell KATP channel activity and membrane-binding studies with nateglinide: a comparison with sulfonylureas and repaglinide
- Nateglinide (a review)
- Nateglinide quantification in rabbit plasma by HPLC: Optimization and application to pharmacokinetic study
- Development and validation of a stereoselective HPLC method for the determination of the in vitro transport of nateglinide enantiomers in rat intestine
考研文獻
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