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CAS RN: 82956-11-4 | 產品號碼: N0959
Nafamostat Mesylate
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補充產品訊息:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 95.0 % |
性質
| 熔點 | 258 °C |
| 水溶性 | Soluble |
| 溶解性（不溶於） | Ether, Acetone |
GHS
相關法規
| RTECS # | DG2736000 |
運輸資料
| HS編碼* | 2925.29-000 |
Application
セリンプロテアーゼ阻害剤，ナファモスタットメシル酸塩
Nafamostat mesilate was first reported by Fujii and Hitomi in 1981 as a synthetic serine protease inhibitor. This compound inhibits various serine protease generated during the coagulation cascade and the inflammatory process. Nafamostat mesilate has been commonly used as an anticoagulant and reported as a drug for the treatments of DIC (disseminated intravascular coagulation) and acute pancreatitis and as an anticoagulant in extracorporeal circulation. (The product is for research purpose only.)
References
- New synthetic inhibitors of C1r, C1 esterase, thrombin, plasmin, kallikrein and trypsin.
- Pharmacological studies of FUT-175, nafamstat mesylate. I. Inhibition of protease activity in in vitro and in vivo experiments
- Nafamostat mesilate (a review)
- Potent pruritogenic action of tryptase mediated by PAR-2 receptor and its involvement in anti-pruritic effect of nafamostat mesilate in mice
- Involvement of human blood arylesterases and liver microsomal carboxylesterases in nafamostat hydrolysis
考研文獻
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