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CAS RN: 698387-09-6 | 產品號碼: N1062
Neratinib
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| 包裝 | 價格 | 同一天 | 2-3个工作日 | 左側以上貨期 |
貨期資訊
|
|---|---|---|---|---|---|
| 100MG |
NT$3,444
|
9 | 0 | 下單後約2週內可以出貨 |
* 以上價格已含運費關稅等但一些需要海運以及乾冰運輸的產品除外,詳情請與
當地經銷商
洽詢。
* TCI會時常優化儲存條件,儲存溫度請以在線目錄為準，敬請留意。
| 產品號碼 | N1062 |
純度/分析方法 
|
>95.0%(T)(HPLC) |
| 分子式 / 分子量 | C__3__0H__2__9ClN__6O__3 = 557.05 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Frozen (<0°C) |
| 應避免的情況 | Heat Sensitive |
| 包裝和容器
|
100MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 698387-09-6 |
| Reaxys-RN | 9971763 |
| PubChem Substance ID | 468592465 |
| MDL編號 | MFCD09752958 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Volumetric Analysis) | min. 95.0 % |
| Melting point | 182.0 to 186.0 °C |
| NMR | confirm to structure |
性質
| 熔點 | 184 °C |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. |
相關法規
運輸資料
| HS編碼* | 2933.49-000 |
Application
Neratinib: A Receptor Tyrosine Kinase Inhibitor of HER1 (EGFR), HER2 and HER4
Neratinib (HKI-272) is a receptor tyrosine kinase inhibitor that irreversibly binds to epidermal growth factor receptors HER1 (EGFR), HER2, and HER4. It has been reported that neratinib reduces EGFR and HER-2 receptor autophosphorylation with inhibition of cell proliferation and functions. Neratinib is highly active against HER2-overexpressing human breast cancer cell lines, and have been mainly used in the treatment of breast cancer. (The product is for research purpose only.)
References
- Antitumor Activity of HKI-272, an Orally Active, Irreversible Inhibitor of the HER-2 Tyrosine Kinase
- Optimization of 6,7-Disubstituted-4-(arylamino)quinoline-3-carbonitriles as Orally Active, Irreversible Inhibitors of Human Epidermal Growth Factor Receptor-2 Kinase Activity
- The development of HKI-272 and related compounds for the treatment of cancer (a review)
- Neratinib: First Global Approval (a review)
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