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CAS RN: 31430-18-9 | 產品號碼: N1138
| 產品號碼 | N1138 |
純度/分析方法 
|
>98.0%(HPLC) |
| 分子式 / 分子量 | C__1__4H__1__1N__3O__3S = 301.32 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Frozen (<0°C) |
| 應避免的情況 | Heat Sensitive |
| 包裝和容器
|
100MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 31430-18-9 |
| Reaxys-RN | 1085978 |
| PubChem Substance ID | 468592478 |
產品規格
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| NMR | confirm to structure |
性質
| 熔點 | 260 °C(dec.) |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H361 : Suspected of damaging fertility or the unborn child. H341 : Suspected of causing genetic defects. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相關法規
| RTECS # | DD6521000 |
運輸資料
| HS編碼* | 2934.99-000 |
Application
CRISPR Genome Editing
The combination of cell cycle regulators, Nocodazole and CCND1 (cyclin D1), enhances CRISPR-mediated homology-directed repair (HDR) efficiency.1)
References
- 1) Efficient precise knockin with a double cut HDR donor after CRISPR/Cas9-mediated double-stranded DNA cleavage
Application
Nocodazole: A Reversible Inhibitor of Polymerization of Microtubules
Nocodazole is a reversible inhibitor of polymerization of microtubules, and it binds with high affinity to tubulin and to inhibit microtubule assembly. Nocodazole has long been used as an experimental tool in cell biology.
References
- Production of large numbers of mitotic mammalian cells by use of the reversible microtubule inhibitor nocodazole. Nocodazole accumulated mitotic cells
- Effects of vinblastine, podophyllotoxin and nocodazole on mitotic spindles: implications for the role of microtubule dynamics in mitosis
- Nanomolar concentrations of nocodazole alter microtubule dynamic instability in vivo and in vitro
- GEF-H1 couples nocodazole-induced microtubule disassembly to cell contractility via RhoA
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