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CAS RN: 57-83-0 | 產品號碼: P0478
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(UV-vis method) | 97.0 to 103.0 % |
| Melting point | 128.0 to 133.0 °C |
| Specific rotation [a]20/D | +179.0 to +185.0 deg(C=2, Dioxane) |
| Solubility in Methanol | almost transparency |
| NMR | confirm to structure |
性質
| 熔點 | 131 °C |
| 比旋光 [α]D | 182° (C=2,Dioxane) |
| 水溶性 | Insoluble |
| Degree of solubility in water | 8.8 mg/l 25 °C |
| 溶解性（可溶於） | Dioxane, Alcohol, Acetone |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H351 : Suspected of causing cancer. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相關法規
| RTECS # | TW0175000 |
運輸資料
| HS編碼* | 2937.23-000 |
Application
Bacterial spore germinant research
Bacterial spores are more resistant to antibiotics and nutritional deficiencies than their vegetative cells and sometimes cause serious problems from the viewpoint of hygiene in clinical treatment and food processing.1) Spore persistence also plays a major role in the recurrence of infections after antibiotic treatment. Molecules that stimulate germination are termed “germinants”1) and the efficacy of germinant administration combined with antibiotics have been evaluated (for example, reports by N. Budi et al.2,3)). Progesterone has been reported to act as a germinant for Clostridium sordellii spores (EC50 = 27.7 μM) and as an inhibitor for Clostridium difficle spores (IC50 = 80.5 μM).4)
(The product is for research purpose only.)
(The product is for research purpose only.)
References
- 1) Germinants and Their Receptors in Clostridia
- 2) Omadacycline Compared to Vancomycin When Combined with Germinants To Disrupt the Life Cycle of Clostridioides difficile.
- 3) Efficacy of Omadacycline or Vancomycin Combined With Germinants for Preventing Clostridioides difficile Relapse in a Murine Model
- 4) Progesterone Analogs Influence Germination of Clostridium sordellii and Clostriduim difficile Spores In Vitro
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