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CAS RN: 518-28-5 | 產品號碼: P1771
Podophyllotoxin
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| 產品號碼 | P1771 |
| 純度/分析方法 | >95.0%(HPLC) |
| 分子式 / 分子量 | C__2__2H__2__2O__8 = 414.41 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 應避免的情況 | Heat Sensitive |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 518-28-5 |
| Reaxys-RN | 99163 |
| PubChem Substance ID | 468592573 |
| Merck Index(14) | 7546 |
| MDL編號 | MFCD00075290 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Melting point | 177.0 to 185.0 °C |
| Specific rotation [a]20/D | -125 to -133 deg(C=1, CHCL3) |
性質
| 熔點 | 181 °C |
| 比旋光 [α]D | -129° (C=1,CHCl3) |
| Maximum Wavelength | 292 nm (MeOH) |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H310 : Fatal in contact with skin. H301 : Toxic if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P262 : Do not get in eyes, on skin, or on clothing. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P361 + P364 : Take off immediately all contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P302 + P352 + P310 : IF ON SKIN: Wash with plenty of water. Immediately call a POISON CENTER/doctor. P405 : Store locked up. |
相關法規
| RTECS # | LV2500000 |
運輸資料
| UN編號 | UN2811 |
| 類別 | 6.1 |
| 包裝類別 | II |
| HS編碼* | 3002.90-000 |
Application
Podophyllotoxin: A Lignin with Antineoplastic and Antiviral Properties
Podophyllotoxin is a naturally occurring lignan isolated from Podophyllum peltatum, with important antineoplastic and antiviral properties. Although the exact mechanism of action is unknown, podophyllotoxin is believed to exert its antimitotic effect by binding to tubulin. In addition, podophyllotoxin derivatives, such as etoposide [E0675] and teniposide [T3109], act as topoisomerase II inhibitors and can cause arrest in the cell cycle of tumor at the G2/M stage. (The product is for research purpose only.)
References
- Discovery of podophyllotoxins (a review)
- Podophyllotoxin (a review)
- Podophyllotoxin: distribution, sources, applications and new cytotoxic derivatives (a review)
- A review on hemisynthesis, biosynthesis, biological activities, mode of action, and structure-activity relationship of podophyllotoxins: 2003-2007
- Recent Advances in the Chemistry and Biology of Podophyllotoxins
- Separation, determination, and identification of the diastereoisomers of podophyllotoxin and its esters by high-performance liquid chromatography/tandem mass spectrometry
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