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CAS RN: 48208-26-0 | 產品號碼: P2023
N-Phthalyl-L-tryptophan
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| 產品號碼 | P2023 |
純度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__1__9H__1__4N__2O__4 = 334.33 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Frozen (<0°C) |
| 應避免的情況 | Heat Sensitive |
| 包裝和容器
|
200MG-Glass Bottle with Plastic Insert （閲覽圖片）, 50MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 48208-26-0 |
| Reaxys-RN | 4552782 |
| PubChem Substance ID | 253661522 |
| MDL編號 | MFCD08705332 |
產品規格
| Appearance | Light yellow to Amber to Dark green powder to crystaline |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Specific rotation [a]20/D | -268 to -273 deg(C=1, EtOH) |
性質
| 熔點 | 181 °C |
| 比旋光 [α]D | -271° (C=1,EtOH) |
| 溶解性（微溶於） | Methanol |
GHS
相關法規
運輸資料
| HS編碼* | 2933.99-000 |
Application
Research on regenerative medicine
RG 108 enhances reprogramming of human1) and mouse2,3) somatic cells to iPS cells.
References
- 1) Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes
- 2) Efficient non-viral reprogramming of myoblasts to stemness with a single small molecule to generate cardiac progenitor cells
- 3) Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds
Application
RG108: A Non-Nucleoside DNA Methyltransferase (DNMT) Inhibitor
DNA methylation regulates epigenetic gene expression in normal and malignant cells. N-phthaloyl-L-tryptophan (RG108) is a non-nucleoside DNA methyltransferase (DNMT) inhibitor. RG108 significantly reduces the methylation of genomic DNA in cells without any detectable toxicity, distinguishing it from nucleoside-based DNA DNMT inhibitors like 5-azacytidine [A2033], 5-aza-2’-deoxycytidine [A2232] and zebularine [Z0022]. RG108 is useful for the experimental modulation of epigenetic gene regulation.
References
- Epigenetic Reactivation of Tumor Suppressor Genes by a Novel Small-Molecule Inhibitor of Human DNA Methyltransferases
- Functional Diversity of DNA Methyltransferase Inhibitors in Human Cancer Cell Lines
- Antileukemic activity of combined epigenetic agents, DNMT inhibitors zebularine and RG108 with HDAC inhibitors, against promyelocytic leukemia HL-60 cells
- DNA methyltransferase inhibitor RG108 and histone deacetylase inhibitors cooperate to enhance NB4 cell differentiation and E-cadherin re-expression by chromatin remodelling
- Epigenetic-based therapies in cancer: progress to date (a review)
PubMed Literature
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