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CAS RN: 1263-89-4 | 產品號碼: P2092
Paromomycin Sulfate
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| 產品號碼 | P2092 |
純度/分析方法 
|
>92.0%(HPLC) |
| 分子式 / 分子量 | C__2__3H__4__5N__5O__1__4·xH__2SO__4 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| 包裝和容器
|
1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 1263-89-4 |
| 相關CAS RN
|
7542-37-2&84420-34-8 |
| PubChem Substance ID | 253662559 |
| Merck Index(14) | 7041 |
| MDL編號 | MFCD00079278 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 92.0 area% |
| Specific rotation [a]20/D | +47.0 to +55.0 deg(C=1, H2O) |
性質
| 比旋光 [α]D | 48° (C=1,H2O) |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防範說明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相關法規
| RTECS # | WK2320000 |
運輸資料
| HS編碼* | 2941.90-000 |
Application
Paromomycin: An Aminoglycoside Antibiotic against Bacteria, Protozoa and Cestodes
Paromomycin is an aminoglycoside antibiotic, first isolated from various Streptomyces in the 1950s. It is active against Gram-negative and many Gram-positive bacteria as well as some protozoa and cestodes. Paromomycin irreversibly binds to the 30S subunit (16S rRNA) of the bacterial ribosome as with any other aminoglycoside antibiotics, and then it inhibits bacterial growth by inhibiting protein synthesis. Paromomycin is mainly used for treatment of leishmaniasis and amoebic dysentery. (The product is for research purpose only.)
References
- Comparisons of ribosomal RNA sequences from amitochondrial protozoa: implications for processing, mRNA binding and paromomycin susceptibility
- The conformation of ribosomes and rRNA (a review)
- rRNA chemical groups required for aminoglycoside binding
- Paromomycin in the treatment of leishmaniasis
- Paromomycin (a review)
- A chemical assessment and HPLC assay validation of bulk paromomycin sulfate
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