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CAS RN: 59-33-6 | 產品號碼: P2369
Pyrilamine Maleate
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| 產品號碼 | P2369 |
純度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__1__7H__2__3N__3O·C__4H__4O__4 = 401.46 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| 應避免的情況 | Light Sensitive |
| CAS RN | 59-33-6 |
| 相關CAS RN
|
91-84-9 |
| Reaxys-RN | 3836479 |
| PubChem Substance ID | 354333684 |
| Merck Index(14) | 7984 |
| MDL編號 | MFCD00069333 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 %(total of Ion-Pair) |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 100.0 to 104.0 °C |
性質
| 熔點 | 102 °C |
| Maximum Wavelength | 310 nm (EtOH) |
| 水溶性 | Soluble |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H302 : Harmful if swallowed. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相關法規
| RTECS # | UT1225000 |
運輸資料
| HS編碼* | 2933.39-000 |
Application
Pyrilamine Maleate: A First Generation Histamine H1 Receptor Antagonist
Pyrilamine maleate, also known as pyrilamine maleate, is a first generation histamine H1 receptor antagonist. Pyrilamine binds to a G protein-coupled form of the receptor and promotes a G protein-coupled inactive state of the H1 receptor that interferes with the Gq/11-mediated signaling. Pyrilamine permeates the blood-brain barrier causing drowsiness. Pyrilamine also has anticholinergic properties. For reference, we also have related first generation histamine H1 receptor antagonists, such as pheniramine maleate [P2271], chlorpheniramine maleate [C0873] and bromopheniramine maleate [B5167]. (The product is for research purpose only.)
References
- Physical and biological properties of pyrilamine (a review)
- Histaminergic systems and sleep. Studies in man with H1 and H2 antagonists
- Influence of certain H1-blockers on the step-through active avoidance response in rats
- Mepyramine, a Histamine H1 Receptor Inverse Agonist, Binds Preferentially to a G Protein-coupled Form of the Receptor and Sequesters G Protein
- Delineation of receptor-ligand interactions at the human histamine H1 receptor by a combined approach of site- directed mutagenesis and computational techniques - or - how to bind the H1 receptor (a review)
- Simultaneous determination of pseudoephedrine, pheniramine, guaifenesin, pyrilamine, chlorpheniramine and dextromethorphan in cough and cold medicines by high performance liquid chromatography
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