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CAS RN: 171179-06-9 | 產品號碼: P2567
產品規格
| Appearance | White to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Elemental analysis(Nitrogen) | 20.00 to 22.00 % |
| Melting point | 174.0 to 178.0 °C |
| NMR | confirm to structure |
性質
| 熔點 | 176 °C |
GHS
相關法規
運輸資料
| HS編碼* | 2933.99-000 |
Application
PD 158780: A Potent Tyrosine Kinase Inhibitor Belongs to Pyridopyrimidines
PD 158780 is a potent tyrosine kinase inhibitor which belongs to chemical class pyridopyrimidines. It has been characterized with respect to enzymology, target specificity, and antiproliferative effects in tumor cells. For example, it shows high specificity for inhibiting the epidermal growth factor receptor (EGFR), and other members of the erbB family, by competitive binding at the ATP site of these signal transduction enzymes.
References
- Tyrosine Kinase Inhibitors. 14. Structure-Activity Relationships for Methyl- amino-Substituted Derivatives of 4-[(3-Bromophenyl)amino]-6-(methylamino)- pyrido[3,4-d]pyrimidine (PD 158780), a Potent and Specific Inhibitor of the Tyrosine Kinase Activity of Receptors for the EGF Family of Growth Factors
- Biochemical and antiproliferative properties of 4-[ar(alk)ylamino]pyridopyrimidines, a new chemical class of potent and specific epidermal growth factor receptor tyrosine kinase inhibitor
考研文獻
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