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CAS RN: 104632-26-0 | 產品號碼: P2879
| 產品號碼 | P2879 |
純度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__1__0H__1__7N__3S = 211.33 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Heat Sensitive |
| 包裝和容器
|
1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 104632-26-0 |
| Reaxys-RN | 6479326 |
| PubChem Substance ID | 468592760 |
| MDL編號 | MFCD00869076 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 127.0 to 131.0 °C |
| Specific rotation | -95.0 ～ -99.0 deg (C=1, methanol) |
| NMR | confirm to structure |
性質
| 熔點 | 129 °C |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防範說明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相關法規
| RTECS # | DL3360000 |
運輸資料
| HS編碼* | 2934.20-000 |
Application
A Dopamine D3 Receptor Agonist, Pramipexole
Pramipexole and its dihydrochloride [P2073] are non-ergot dopamine agonists with high relative specificity and full intrinsic activity at the D2 subfamily (D2, D3, D4) of dopamine receptors. The affinity for the D3 receptor subtype is the highest. Specifically, pramipexoles have selective affinity for the D2 subfamily (D2, D3, D4), with a 7-10 fold greater affinity for D3 than for D2 receptor subtypes; affinity for the D4 receptor subtype is 17-fold less than for D3 receptors.1) In clinical, the dihydrochloride is used for the treatment of Parkinson's disease.2,3) Although the precise mechanism of action is unknown, it is believed to be related to its ability to stimulate dopamine receptors in the striatum. (The product is for research purpose only.)
References
- 1) Pramipexole binding and activation of cloned and expressed dopamine D2, D3 and D4 receptors
- 2) Pharmacology of pramipexole, a dopamine D3-preferring agonist useful in treating Parkinson's disease (a review)
- 3) Dopamine D3 receptor agonists for protection and repair in Parkinson's disease (a review)
- 4) Validated chiral liquid chromatographic method for the enantiomeric separation of Pramipexole dihydrochloride monohydrate
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