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CAS RN: 117976-90-6 | 產品號碼: R0115
Rabeprazole Sodium Salt
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| 產品號碼 | R0115 |
| 純度/分析方法 | >98.0%(HPLC) |
| 分子式 / 分子量 | C__1__8H__2__0N__3NaO__3S = 381.43 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Frozen (<0°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Hygroscopic,Heat Sensitive |
| 包裝和容器 | 100MG-Glass Bottle with Plastic Insert （閲覽圖片）, 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 117976-90-6 |
| 相關CAS RN | 117976-89-3 |
| Reaxys-RN | 7561607 |
| PubChem Substance ID | 253660182 |
| Merck Index(14) | 8089 |
| MDL編號 | MFCD02092688 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 95.0 % |
| NMR | confirm to structure |
性質
| 熔點 | 150 °C |
| 溶解性（可溶於） | Methanol |
| 溶解性（不溶於） | Ether |
GHS
相關法規
運輸資料
| HS編碼* | 2933.99-000 |
Application
A More Potent Proton Pump Inhibitor, Rabeprazole Sodium
Rabeprazole sodium is a new substituted benzimidazole proton pump inhibitor with several differences compared with existing proton pump inhibitors. Rabeprazole sodium is a more potent inhibitor of H+,K+-ATPase (hydrogen-potassium adenosine triphosphatase) and acid secretion than omeprazole [O0359], and is a more rapid inhibitor of proton pumps than omeprazole, lansoprazole [L0233], or pantoprazole sulfide [P2066]. Furthermore, in vitro studies have shown that rabeprazole sodium possesses more potent antibacterial properties against the growth of H. pylori than other proton pump inhibitors.
References
- The pharmacology of rabeprazole
- Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities
- Gastric acid control with esomeprazole, lansoprazole, omeprazole, pantoprazole, and rabeprazole: a five-way crossover study
- Effects of CYP2C19 genotypic differences in the metabolism of omeprazole and rabeprazole on intragastric pH
- In Vitro Activities of Rabeprazole, a Novel Proton Pump Inhibitor, and Its Thioether Derivative Alone and in Combination with Other Antimicrobials against Recent Clinical Isolates of Helicobacter pylori
考研文獻
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