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CAS RN: 85416-73-5 | 產品號碼: R0183
(S)-(+)-Rolipram
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產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Optical purity(LC) | min. 97.0 ee% |
| Elemental analysis(Nitrogen) | 4.50 to 5.50 % |
| Melting point | 132.0 to 136.0 °C |
| Specific rotation [a]20/D | +29.0 to +34.0 deg(C=0.5, MeOH) |
| NMR | confirm to structure |
性質
| 熔點 | 134 °C |
| 比旋光 [α]D | 32° (C=0.5,MeOH) |
GHS
相關法規
運輸資料
| HS編碼* | 2933.79-000 |
Application
(S)-(+)-Rolipram: The Less Active Enantiomer of Rolipram, PDE4 Inhibitor
(S)-(+)-Rolipram is the less active enantiomer of the PDE4 inhibitor rolipram [R0110]. The active enantiomer (R)-(-)-rolipram [R0182] also available. It has been reported that (S)-(-)-rolipram is approximately 3 times less potent than (R)-(+)-rolipram against PDE4. In 2015, Kobayashi et al. have been reported a new multistep continuous-flow synthesis of (R)- and (S)-rolipram using only columns packed with heterogeneous catalysts. (The product is for research purpose only.)
References
- Stereospecificity of rolipram actions on eosinophil cyclic AMP-specific phosphodiesterase
- Emesis induced by inhibitors of type IV cyclic nucleotide phosphodiesterase (PDE IV) in the ferret
- Multistep continuous-flow synthesis of (R)- and (S)-rolipram using heterogeneous catalysts
- Flow “Fine” Synthesis: High Yielding and Selective Organic Synthesis by Flow Methods
考研文獻
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