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CAS RN: 144875-48-9 | 產品號碼: R0197
補充產品訊息:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| 產品號碼 | R0197 |
純度/分析方法
|
>98.0%(HPLC) |
| 分子式 / 分子量 | C__1__7H__2__2N__4O__2 = 314.39 |
| 外觀與形狀(20°C) | Solid |
儲存條件
|
Frozen (-20°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Hygroscopic,Heat Sensitive |
包裝和容器
|
100MG-Glass Bottle with Plastic Insert (閲覽圖片), 25MG-Glass Bottle with Plastic Insert (閲覽圖片) |
| CAS RN | 144875-48-9 |
| Reaxys-RN | 9792901 |
| PubChem Substance ID | 354335079 |
| Merck Index(14) | 8151 |
| MDL編號 | MFCD00937759 |
產品規格
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
性質
| 熔點 | 193 °C |
| Maximum Wavelength | 325 nm |
GHS
相關法規
| RTECS # | NJ5911320 |
運輸資料
| HS編碼* | 2933.99-000 |
Application
Resiquimod: A Toll-Like Receptor Agonist
Resiquimod (R-848) is a tricyclic imidazoquinolone compound and an imiquimod [I0747] analog. Toll-like receptors (TLRs) play an important role in the innate immune response to pathogens. Reportedly, resiquimod act as an immunomodulator and an anti-viral agent through activation immune cells via the Toll-like receptor 7 and 7/8 (TLR7 and TLR7/8) dependent signaling pathway. And then, resiquimod induces mRNA encoding cytokines including interferon-α (INF-α) at the treatment site. (The product is for research purpose only.)
References
- Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
- Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848
- Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells
- The antiviral activity of toll-like receptor 7 and 7/8 agonists (a review)
- The use of Toll-like receptor 7/8 agonists as vaccine adjuvants (a review)
PubMed Literature
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