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CAS RN: 196597-26-9 | 產品號碼: R0216
| 產品號碼 | R0216 |
| 純度/分析方法 | >98.0%(GC) |
| 分子式 / 分子量 | C__1__6H__2__1NO__2 = 259.35 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 包裝和容器 | 100MG-Glass Bottle with Plastic Insert （閲覽圖片）, 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 196597-26-9 |
| Reaxys-RN | 9277585 |
| PubChem Substance ID | 468592788 |
| Merck Index(14) | 8101 |
| MDL編號 | MFCD08067736 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 114.0 to 118.0 °C |
| Specific rotation [a]20/D | -55.0 to -60.0 deg(C=1, CHCL3) |
性質
| 熔點 | 116 °C |
| 比旋光 [α]D | -57° (C=1,CHCl3) |
| 水溶性 | Insoluble |
| Degree of solubility in water | 11 mg/l 25 °C |
| 溶解性（可溶於） | Ethanol |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H302 : Harmful if swallowed. H361 : Suspected of damaging fertility or the unborn child. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
相關法規
| RTECS # | TX1498230 |
運輸資料
| HS編碼* | 2932.99-000 |
Application
Ramelteon: A Selective Melatonin MT1 and MT2 Receptors Agonist
Ramelteon (TAK-375) is a melatonin [M1105] receptor agonist with both high affinity for melatonin MT1 and MT2 receptors, and high selectivity for MT1 and MT2 receptors compared to the MT3 receptor. In addition, ramelteon showed no measurable affinity for a large number of ligand binding sites, including benzodiazepine receptors, dopamine receptors, opiate receptors, ion channels, and transporters. Ramelteon also does not interfere with the activity of a number of enzymes. The agonist activity at the MT1 and MT2 receptors has been reported to contribute to its sleep-promoting properties. And then, ramelteon currently is approved in the United States and Japan for the treatment of insomnia. (The product is for research purpose only.)
References
- Neurochemical properties of ramelteon (TAK-375), a selective MT1/MT2 receptor agonist
- Pharmacology of ramelteon, a selective MT1/MT2 receptor agonist: a novel therapeutic drug for sleep disorders (a review)
- Enantiomeric separation of a melatonin agonist Ramelteon using amylose-based chiral stationary phase
- メラトニン受容体作動薬ラメルテオン (ロゼレム®錠8 mg) の薬理作用と臨床試験成績
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