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CAS RN: 446859-33-2 | 產品號碼: R0224
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 193.0 to 197.0 °C |
性質
| 熔點 | 195 °C |
GHS
相關法規
運輸資料
| HS編碼* | 2933.99-000 |
Application
TGF-β Type I Receptor Inhibitor
RepSox (1) is a cell permeable TGF-β type I receptor inhibitor. 1 shows inhibition properties on ALK5 as shown in Table 1 and less potent activity against 9 other related kinases, including p38 MAPK, JNK1, and GSK3 (IC50 > 16 μM).1) 1 promotes reprogramming of human and mouse embryonic fibroblasts to induced pluripotent stem cells (iPSCs).2,3) In addition, it was also reported that 1 induces human ESCs and iPSCs into glucagon-producing cells and insulin-producing cells, respectively.4,5)
References
- 1) Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-β type I receptor inhibitors
- 2) A small-molecule inhibitor of Tgf-β signaling replaces Sox2 in reprogramming by inducing Nanog
- 3) Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells
- 4) Small molecules induce efficient differentiation into insulin-producing cells from human induced pluripotent stem cells
- 5) Production of functional glucagon-secreting α-cells from human embryonic stem cells
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