Maximum quantity allowed is 999
请选择数量
CAS RN: 161265-03-8 | 產品號碼: R0300
Xantphos (HPMC encapsulated)
×
![]()
×
* 以上價格已含運費關稅等但一些需要海運以及乾冰運輸的產品除外,詳情請與
當地經銷商
洽詢。
* TCI會時常優化儲存條件,儲存溫度請以在線目錄為準，敬請留意。
補充產品訊息:
Contents (per one capsule)
- Xantphos ca. 0.125 mmol
Uses of Reagent
- Applicable to palladium-catalyzed reactions due to a ligand encapsulated in HPMC capsules
Soluble Solvents
- Water, DMSO, DMF, 1,4-Dioxane (50°C), THF/Water mixture, 1,2-Dimethoxyethane/Water mixture
Related Product
- B2709 4,5-Bis(diphenylphosphino)-9,9-dimethylxanthene
| 產品號碼 | R0300 |
| 分子式 / 分子量 | C__3__9H__3__2OP__2 = 578.63 |
| 外觀與形狀（20°C） | Solid |
儲存條件 
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Hygroscopic |
| CAS RN | 161265-03-8 |
產品規格
| Appearance | White to Almost white capsule |
| Functionality test (conversion ratio) | min.90.0 % |
性質
GHS
相關法規
運輸資料
| HS編碼* | 3822.19-000 |
Application
TCI Practical Example: Suzuki-Miyaura Coupling Using the Encapsulated Pd2(dba)3 and Xantphos
-
Used Chemicals
-
Procedure
-
Pd2(dba)3 (HPMC encapsulated) (one capsule) and Xantphos (HPMC encapsulated) (one capsule) were added to a solution of 2-acetamido-5-bromo-4-methylpyridine (570 mg, 2.50 mmol), cesium carbonate (900 mg, 2.80 mmol, 1.1 eq.) and phenylboronic acid (460 mg, 3.80 mmol, 1.5 eq.) in THF/water (4:1, 20 mL) at room temperature and the reaction mixture was stirred at 100 °C for 2 hours. The solution was then diluted with ethyl acetate (3.2 mL) and sat. Na2SO4 aq. (3.2 mL), and filtered through Celite pad and the filtrate was extracted with ethyl acetate (10 mL x 3). The organic layer was washed with water (15 mL) and brine (15 mL), dried over sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel chromatography (ethyl acetate:hexane = 0:1 - 4:1) to afford 2-acetamido-4-methyl-5-phenylpyridine (408 mg, 72% yield) as a pale yellow solid.
-
Experimenter’s Comments
-
The reaction mixture was monitored by GC.
The material of the capsule is water-soluble HPMC (hydroxypropyl methylcellulose).
The shape of the capsule is like the image below and Pd2(dba)3 (ca. 60 μmol) and Xantphos (ca. 125 μmol) are encapsulated in each capsule, respectively.
The capsule disintegrates as shown in the image below when stirred in the solvent for about 15 minutes, releasing its content.
-
Analytical Data
-
2-Acetamido-4-methyl-5-phenylpyridine
1H NMR (400 MHz, CDCl3); δ 9.24-9.06 (brs, 1H), 8.16 (s, 1H), 8.10 (s, 1H), 7.46-7.36 (m, 3H), 7.30-7.29 (m, 2H), 2.32 (s, 3H), 2.21 (s, 3H).
-
Lead Reference
-
- Reagent and Catalyst Capsules: A Chemical Delivery System for Reaction Screening and Parallel Synthesis
-
Other References
-
- HPMC: A Biomass-Based Semisynthetic Sustainable Additive Enabling Clean and Fast Chemistry in Water
產品文件 （部分產品的分析圖譜無法提供，敬請諒解。）
SDS
請選擇語言。
請求的SDS不可用。
如需更多幫助，請聯繫我們 。
產品規格
檢驗報告(CoA)及其他文檔
請輸入批號
輸入的批號不正確
示例 CoA
可下載CoA示例。注：該示例可能非最新批次的CoA。
目前沒有該產品的 CoA 示例。
分析圖譜
請輸入批號
輸入的批號不正確
很抱歉，您搜索的分析圖譜無法提供。